Benzofuran, 2-(4-chlorophenyl)-5-nitro-

Base Information

• Chemical Name: Benzofuran, 2-(4-chlorophenyl)-5-nitro-
• CAS No.: 101993-21-9
• Molecular Formula: C14H8ClNO3
• Molecular Weight: 273.675
• Mol file: 101993-21-9.mol

Synonyms:

Chemical Property of Benzofuran, 2-(4-chlorophenyl)-5-nitro-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzofuran, 2-(4-chlorophenyl)-5-nitro-

There total 7 articles about Benzofuran, 2-(4-chlorophenyl)-5-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C14H9BrClNO3 → 2-(4-chlorophenyl)-5-nitrobenzofuran (101993-21-9)

Guidance literature:

With potassium carbonate; palladium dichloride; In N,N-dimethyl-formamide; at 130 ℃; for 6h; under air; sealed tube;

DOI:10.1021/ol202383z

Reference yield: 55.0%

4-vinylbenzyl chloride (1073-67-2,24991-47-7) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 2-(4-chlorophenyl)-5-nitrobenzofuran (101993-21-9)

Guidance literature:

With 1,10-Phenanthroline; copper(II) acetate hydrate; sodium acetate; palladium diacetate; In 1,2-dichloro-ethane; at 110 ℃; for 24h; Molecular sieve;

DOI:10.1002/anie.201305326

Reference yield: 7.0%

4-n-chlorophenylacetylene (873-73-4) + 2-iodo-4-nitrophenol (89487-91-2) → 2-(4-chlorophenyl)-5-nitrobenzofuran (101993-21-9)

Guidance literature:

2-iodo-4-nitrophenol; With copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; 2-hydroxymethylpyrrolidine; In water; at 20 ℃; for 1h;

4-n-chlorophenylacetylene; In water; at 80 ℃; for 2h;

DOI:10.1021/jm200135z

upstream raw materials:

4-n-chlorophenylacetylene

2-iodo-4-nitrophenol

2-Iodophenol

4-nitro-phenol

Downstream raw materials:

2-(4-chlorophenyl)benzofuran-5-amine

2-(4-chlorophenyl)-5-isobutyramido-benzofuran

Refernces

• 1、 Rao, Maddali L. N.,Dasgupta, Priyabrata. "A concise route to functionalized benzofurans directly from gem-dibromoalkenes and phenols". . p. 65462 - 65470. Retrieved 2015/08/18.
• 2、 Chancellor, Daniel R.,Davies, Kay E.,De Moor, Olivier,Dorgan, Colin R.,Johnson, Peter D.,Lambert, Adam G.,Lawrence, Daniel,Lecci, Cristina,Maillol, Carole,Middleton, Penny J.,Nugent, Gary,Poignant, Séverine D.,Potter, Allyson C.,Price, Paul D.,Pye, Richard J.,Storer, Richard,Tinsley, Jonathon M.,Van Well, Renate,Vickers, Richard,Vile, Julia,Wilkes, Fraser J.,Wilson, Francis X.,Wren, Stephen P.,Wynne, Graham M.. "Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of duchenne muscular dystrophy". supporting information; experimental part. p. 3241 - 3250. Retrieved 2011/07/06.