(-)-methaqualone

Base Information

Chemical Name:(-)-methaqualone
CAS No.:81882-39-5
Molecular Formula:C₁₆H₁₄N₂O
Molecular Weight:250.3
Hs Code.:

Synonyms:

Suppliers and Price of (-)-methaqualone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-methaqualone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-methaqualone

There total 13 articles about (-)-methaqualone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 13061-96-6
dihydroxy-methyl-borane

: (P)-3-(2-Bromophenyl)-2-methylquinazolin-4(3H)-one

: 72-44-6,81718-89-0,81882-39-5,93240-42-7
(+)-methaqualone

: 72-44-6,81718-89-0,81882-39-5,93240-42-7
(-)-methaqualone

Guidance literature:: With potassium phosphate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In 1,4-dioxane; at 45 ℃; for 22h;
DOI:10.1021/acs.orglett.6b02865

Reference yield: 40.0%

: 13061-96-6
dihydroxy-methyl-borane

: (P)-3-(2-Bromophenyl)-2-methylquinazolin-4(3H)-one

: 72-44-6,81718-89-0,81882-39-5,93240-42-7
(+)-methaqualone

: 72-44-6,81718-89-0,81882-39-5,93240-42-7
(-)-methaqualone

Guidance literature:: With potassium phosphate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In 1,4-dioxane; at 45 ℃; for 22h;
DOI:10.1021/acs.orglett.6b02865

Reference yield:

: 608-30-0
2,6-dibromoaniline

: 72-44-6,81718-89-0,81882-39-5,93240-42-7
(+)-methaqualone

: 72-44-6,81718-89-0,81882-39-5,93240-42-7
(-)-methaqualone

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus trichloride / toluene / 20 h / 80 - 120 °C / Inert atmosphere

2: palladium diacetate; sodium tetrahydroborate; (R)-DTBM-SEGPHOS / N,N-dimethyl-formamide / 21 h / 0 °C / Inert atmosphere

3: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; potassium phosphate / 1,4-dioxane / 22 h / 45 °C

With sodium tetrahydroborate; potassium phosphate; 1,3-bis-(diphenylphosphino)propane; (R)-DTBM-SEGPHOS; palladium diacetate; phosphorus trichloride; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.orglett.6b02865