3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-methoxycarbonyl-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

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Chemical Name:3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-methoxycarbonyl-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester
CAS No.:402958-58-1
Molecular Formula:C₄₁H₅₆N₈O₇
Molecular Weight:772.945
Hs Code.:

3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-methoxycarbonyl-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

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Chemical Property of 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-methoxycarbonyl-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

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Technology Process of 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-methoxycarbonyl-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

There total 6 articles about 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-methoxycarbonyl-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-methoxycarbonyl-pyrrolidin-3-yl ester

: 402958-47-8
(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyric acid

: 402958-58-1
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-methoxycarbonyl-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide;
DOI:10.1016/j.bmcl.2004.05.078

Reference yield:

: 3009-88-9
5-cyanopentanoic acid methyl ester

: 402958-58-1
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-methoxycarbonyl-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / NaN₃; Et₃N*HCl

2: 95 percent / Cl₃CCO₂H

3: 75 percent / aq. NaOH

4: 75 percent / EDCI; DIEA

5: 91 percent / DIEA

6: 95 percent / HOAt; DCC

With sodium hydroxide; sodium azide; 1-hydroxy-7-aza-benzotriazole; triethylamine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trichloroacetic acid;
DOI:10.1016/j.bmcl.2004.05.078

Reference yield:

: 80486-64-2
methyl 5-(1,2,3,4-tetrazol-5-yl)valerate

: 402958-58-1
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-methoxycarbonyl-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Cl₃CCO₂H

2: 75 percent / aq. NaOH

3: 75 percent / EDCI; DIEA

4: 91 percent / DIEA

5: 95 percent / HOAt; DCC

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trichloroacetic acid;
DOI:10.1016/j.bmcl.2004.05.078