3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

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Chemical Name:3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester
CAS No.:402958-61-6
Molecular Formula:C₄₉H₆₈N₁₀O₈
Molecular Weight:925.141
Hs Code.:

3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

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Chemical Property of 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

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Technology Process of 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

There total 10 articles about 3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 402958-60-5
3,4-dihydro-1H-isoquinoline-2-carboxylic acid 5-[1-(cyclopropylcarbamoyl-hydroxy-methyl)-butylcarbamoyl]-1-[3-methyl-2-(3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

: 402958-61-6
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

Guidance literature:: With Dess-Martin periodane;
DOI:10.1016/j.bmcl.2004.05.078

Reference yield:

: 3009-88-9
5-cyanopentanoic acid methyl ester

: 402958-61-6
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 68 percent / NaN₃; Et₃N*HCl

2: 95 percent / Cl₃CCO₂H

3: 75 percent / aq. NaOH

4: 75 percent / EDCI; DIEA

5: 91 percent / DIEA

6: 95 percent / HOAt; DCC

7: 100 percent / aq. NaOH

8: 60 percent / PyBOP; DIEA

9: Dess-Martin periodinane

With sodium hydroxide; sodium azide; 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine hydrochloride; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trichloroacetic acid; 9: Dess-Martin oxidation;
DOI:10.1016/j.bmcl.2004.05.078

Reference yield:

: 80486-64-2
methyl 5-(1,2,3,4-tetrazol-5-yl)valerate

: 402958-61-6
3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / Cl₃CCO₂H

2: 75 percent / aq. NaOH

3: 75 percent / EDCI; DIEA

4: 91 percent / DIEA

5: 95 percent / HOAt; DCC

6: 100 percent / aq. NaOH

7: 60 percent / PyBOP; DIEA

8: Dess-Martin periodinane

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trichloroacetic acid; 8: Dess-Martin oxidation;
DOI:10.1016/j.bmcl.2004.05.078