Technology Process of 3-Phenanthrenol,
4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, trans-
There total 42 articles about 3-Phenanthrenol,
4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, trans- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at 0 ℃;
for 12h;
DOI:10.1002/bkcs.11538
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 89 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 68 percent / dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH2Cl2 / 2 h / 20 °C
3.1: 65.2 percent / BF3*OEt2 / nitromethane / 4 h / 20 °C
4.1: aq. KOH / ethanol / 10 h / Heating
5.1: 42 percent / Pb(OAc)4; Cu(OAc)2 / pyridine / 6 h / 150 °C
6.1: 85 percent / H2 / 5percent Pd/C / ethyl acetate / 16 h / 20 °C
7.1: 87 percent / AlCl3 / CH2Cl2 / 1.5 h / 20 °C
8.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
8.2: 47 percent / tetrahydrofuran; hexane / 1 h / 0 °C
9.1: H2 / 5percent Pd/C / ethyl acetate / 16 h / 20 °C
10.1: 34 percent / EtSH; NaH / dimethylformamide / 48 h / 120 °C
With
lead(IV) acetate; dmap; potassium hydroxide; n-butyllithium; aluminium trichloride; copper diacetate; boron trifluoride diethyl etherate; hydrogen; sodium hydride; dicyclohexyl-carbodiimide; ethanethiol; lithium diisopropyl amide;
5percent Pd/C;
In
tetrahydrofuran; pyridine; nitromethane; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
1.1: Metallation / 1.2: Alkylation / 2.1: Esterification / 3.1: Cyclization / 4.1: Hydrolysis / 5.1: Decarboxylation / 6.1: Hydrogenation / 7.1: Acetylation / 8.1: Metallation / 8.2: Condensation / 9.1: Hydrogenation / 10.1: Substitution;
DOI:10.1039/b003497p
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-
10064-08-1,10090-67-2,81026-40-6,81026-42-8,109554-02-1,139068-09-0
1,2,3,4,4a,9,10,10a-Octahydro-6-methoxy-1,1,4a-trimethylphenanthrene
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / PPA / 12 h / 10 °C
2: diethyl ether / 1 h / Heating
3: 0.93 g / H2SO4 / 3 h / Heating
4: 70.4 percent / H2 / Pd/C / ethanol / 1034.3 Torr
5: 90.6 percent / aq. HBr; AcOH / 24 h / 20 °C
With
sulfuric acid; hydrogen bromide; hydrogen; acetic acid;
palladium on activated charcoal;
In
diethyl ether; ethanol;
DOI:10.1021/jo049616n