(4aS,10aS)-1,1,4a-Trimethyl-6-methoxy-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene

Base Information Edit

Chemical Name:(4aS,10aS)-1,1,4a-Trimethyl-6-methoxy-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene
CAS No.:10064-26-3
Molecular Formula:C₂₁H₃₂O
Molecular Weight:300.484
Hs Code.:
Mol file:10064-26-3.mol

Synonyms:(+)-Ferruginyl methyl ether;(4aS,10aS)-1,1,4a-Trimethyl-6-methoxy-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene;12-Methoxyabieta-8,11,13-triene;13-Isopropyl-12-methoxypodocarpa-8,11,13-triene

Suppliers and Price of (4aS,10aS)-1,1,4a-Trimethyl-6-methoxy-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of (4aS,10aS)-1,1,4a-Trimethyl-6-methoxy-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene Edit

Chemical Property:

Melting Point:45-48 °C
Boiling Point:390.5±41.0 °C(Predicted)
PSA：9.23000
Density:0.952±0.06 g/cm3(Predicted)
LogP:5.84880

Purity/Quality:: 98%,99%, ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (4aS,10aS)-1,1,4a-Trimethyl-6-methoxy-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene

There total 2 articles about (4aS,10aS)-1,1,4a-Trimethyl-6-methoxy-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5389-87-7
1-chloro-3,7-dimethylocta-2,6-diene

: 10064-26-3,64199-80-0,64998-39-6,70051-26-2,94669-27-9,113059-71-5,113349-89-6
(+/-)-ferruginyl methyl ether

Guidance literature:: Multi-step reaction with 9 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 89 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 68 percent / dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 20 °C

3.1: 65.2 percent / BF₃*OEt₂ / nitromethane / 4 h / 20 °C

4.1: aq. KOH / ethanol / 10 h / Heating

5.1: 42 percent / Pb(OAc)4; Cu(OAc)2 / pyridine / 6 h / 150 °C

6.1: 85 percent / H₂ / 5percent Pd/C / ethyl acetate / 16 h / 20 °C

7.1: 87 percent / AlCl₃ / CH₂Cl₂ / 1.5 h / 20 °C

8.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

8.2: 47 percent / tetrahydrofuran; hexane / 1 h / 0 °C

9.1: H₂ / 5percent Pd/C / ethyl acetate / 16 h / 20 °C

With lead(IV) acetate; dmap; potassium hydroxide; n-butyllithium; aluminium trichloride; copper diacetate; boron trifluoride diethyl etherate; hydrogen; dicyclohexyl-carbodiimide; lithium diisopropyl amide; 5percent Pd/C; In tetrahydrofuran; pyridine; nitromethane; ethanol; hexane; dichloromethane; ethyl acetate; 1.1: Metallation / 1.2: Alkylation / 2.1: Esterification / 3.1: Cyclization / 4.1: Hydrolysis / 5.1: Decarboxylation / 6.1: Hydrogenation / 7.1: Acetylation / 8.1: Metallation / 8.2: Condensation / 9.1: Hydrogenation;
DOI:10.1039/b003497p

Reference yield:

: 4698-08-2
(E)-geranic acid

: 64199-80-0,64998-39-6,70051-26-2,94669-27-9,113059-71-5,113349-89-6,10064-26-3
O-methyl ferruginol

Guidance literature:: Multi-step reaction with 11 steps

1.1: H₃PO₄ / toluene / 2 h / 100 °C

1.2: (-)-α-methylbenzylamine

2.1: 90 percent / K₂CO₃ / acetone / 3 h / 20 °C

3.1: 90 percent / LiAlH₄ / diethyl ether / 1 h / -10 °C

4.1: 75 percent / 4A molecular sieves; NaOAc; PCC / CH₂Cl₂ / 1 h / -10 °C

5.1: n-BuLi / hexane / 1 h / 20 °C

5.2: 60 percent / hexane / 4 h

6.1: 95 percent / H₂ / 10 percent Pd/C / ethanol / 20 °C

7.1: 85 percent / BF₃*Et₂O / CH₂Cl₂

8.1: 95 percent / AlCl₃ / CH₂Cl₂ / -5 °C

9.1: 95 percent / THF / 4 h / 0 °C

10.1: 90 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating

11.1: 95 percent / H₂ / 5 percent Pd/C / ethanol / 20 °C

With tetrahydrofuran; lithium aluminium tetrahydride; n-butyllithium; aluminium trichloride; phosphoric acid; 4 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; sodium acetate; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; palladium on activated charcoal; In diethyl ether; ethanol; hexane; dichloromethane; acetone; toluene; benzene; 1.1: Cyclization / 1.2: racemate resolution / 2.1: Methylation / 3.1: Reduction / 4.1: Oxidation / 5.1: Metallation / 5.2: Condensation / 6.1: Catalytic hydrogenation / 7.1: Cyclization / 8.1: Acetylation / 9.1: Addition / 10.1: Dehydration / 11.1: Catalytic hydrogenation;