Benzenemethanamine, N-methyl-, trifluoroacetate

Base Information

• Chemical Name: Benzenemethanamine, N-methyl-, trifluoroacetate
• CAS No.: 102234-85-5
• Molecular Formula: C8H11N.C2HF3O2
• Molecular Weight: 235.206
• Mol file: 102234-85-5.mol

Synonyms:

Chemical Property of Benzenemethanamine, N-methyl-, trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, N-methyl-, trifluoroacetate

There total 4 articles about Benzenemethanamine, N-methyl-, trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonylbenzylamine (42116-44-9) → N-benzyl-N-methylammonium trifluoroacetate (102234-85-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH; TBAB / tetrahydrofuran / 0.25 h / 20 °C

1.2: tetrahydrofuran / 40 °C

2.1: CH₂Cl₂ / 1 h / 20 °C

With tetrabutylammomium bromide; sodium hydride; In tetrahydrofuran; dichloromethane;

Reference yield:

benzyl bromide (100-39-0) → N-benzyl-N-methylammonium trifluoroacetate (102234-85-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 96 percent / K₂CO₃; TBAB / tetrahydrofuran / 20 °C

2.1: TFA / CH₂Cl₂ / 3 h / 20 °C

3.1: NaH; TBAB / tetrahydrofuran / 0.25 h / 20 °C

3.2: tetrahydrofuran / 40 °C

4.1: CH₂Cl₂ / 1 h / 20 °C

With tetrabutylammomium bromide; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

N,N-bis(tert-butoxycarbonyl)benzylamine (109774-57-4) → N-benzyl-N-methylammonium trifluoroacetate (102234-85-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: TFA / CH₂Cl₂ / 3 h / 20 °C

2.1: NaH; TBAB / tetrahydrofuran / 0.25 h / 20 °C

2.2: tetrahydrofuran / 40 °C

3.1: CH₂Cl₂ / 1 h / 20 °C

With tetrabutylammomium bromide; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

upstream raw materials:

tert-butyl N-benzyl-N-methylcarbamate

trifluoroacetic acid

N-tert-butoxycarbonylbenzylamine

benzyl bromide

Downstream raw materials:

N-(3-butenyl)-N-methylbenzenemethanamine