(1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-tolyl)-2-phenylethylamine

Base Information

• Chemical Name: (1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-tolyl)-2-phenylethylamine
• CAS No.: 84984-03-2
• Molecular Formula: C₂₀H₂₇NO
• Molecular Weight: 297.44
• Mol file: 84984-03-2.mol

Synonyms:

Chemical Property of (1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-tolyl)-2-phenylethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-tolyl)-2-phenylethylamine

There total 7 articles about (1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-tolyl)-2-phenylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-bromoisovalerate (609-12-1) → (1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-tolyl)-2-phenylethylamine (84984-03-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / lithium aluminium hydride / diethyl ether / 1 h

2: 67 percent / anh. Na₂CO₃ / ethanol / 18 h / Heating

3: H₂, cc. HCl / 10percent Pd-C / methanol / 4045.3 Torr

4: 89 percent / diethyl ether / 1 h / Ambient temperature

5: diethyl ether / 20 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium carbonate; palladium on activated charcoal; In methanol; diethyl ether; ethanol;

DOI:10.1248/cpb.30.3160

Reference yield:

2-bromoisovaleric acid (10323-40-7,565-74-2) → (1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-tolyl)-2-phenylethylamine (84984-03-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 81 percent / H₂SO₄ / 2 h / Heating

2: 80 percent / lithium aluminium hydride / diethyl ether / 1 h

3: 67 percent / anh. Na₂CO₃ / ethanol / 18 h / Heating

4: H₂, cc. HCl / 10percent Pd-C / methanol / 4045.3 Torr

5: 89 percent / diethyl ether / 1 h / Ambient temperature

6: diethyl ether / 20 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; hydrogen; sodium carbonate; palladium on activated charcoal; In methanol; diethyl ether; ethanol;

DOI:10.1248/cpb.30.3160

Reference yield:

dl-2-bromo-3-methyl-1-butanol (84984-06-5) → (1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-tolyl)-2-phenylethylamine (84984-03-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 67 percent / anh. Na₂CO₃ / ethanol / 18 h / Heating

2: H₂, cc. HCl / 10percent Pd-C / methanol / 4045.3 Torr

3: 89 percent / diethyl ether / 1 h / Ambient temperature

4: diethyl ether / 20 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium carbonate; palladium on activated charcoal; In methanol; diethyl ether; ethanol;

DOI:10.1248/cpb.30.3160

upstream raw materials:

p-tolyllithium

(E)-(S)-N-(2-hydroxy-1-isopropylethyl)phenylethylideneamine

ethyl 2-bromoisovalerate

(S)-valinol

Downstream raw materials:

(1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-tolyl)-2-phenylethylamine hydrochloride