(E)-(S)-N-(2-hydroxy-1-isopropylethyl)phenylethylideneamine

Base Information

• Chemical Name: (E)-(S)-N-(2-hydroxy-1-isopropylethyl)phenylethylideneamine
• CAS No.: 84984-01-0
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.3
• Mol file: 84984-01-0.mol

Synonyms:

Chemical Property of (E)-(S)-N-(2-hydroxy-1-isopropylethyl)phenylethylideneamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(S)-N-(2-hydroxy-1-isopropylethyl)phenylethylideneamine

There total 5 articles about (E)-(S)-N-(2-hydroxy-1-isopropylethyl)phenylethylideneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(S)-valinol (2026-48-4,473-75-6) + phenylacetaldehyde (122-78-1) → (E)-(S)-N-(2-hydroxy-1-isopropylethyl)phenylethylideneamine (84984-01-0)

Guidance literature:

In diethyl ether; for 1h; Ambient temperature;

DOI:10.1248/cpb.30.3160

Reference yield:

ethyl 2-bromoisovalerate (609-12-1) → (E)-(S)-N-(2-hydroxy-1-isopropylethyl)phenylethylideneamine (84984-01-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / lithium aluminium hydride / diethyl ether / 1 h

2: 67 percent / anh. Na₂CO₃ / ethanol / 18 h / Heating

3: H₂, cc. HCl / 10percent Pd-C / methanol / 4045.3 Torr

4: 89 percent / diethyl ether / 1 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium carbonate; palladium on activated charcoal; In methanol; diethyl ether; ethanol;

DOI:10.1248/cpb.30.3160

Reference yield:

2-bromoisovaleric acid (10323-40-7,565-74-2) → (E)-(S)-N-(2-hydroxy-1-isopropylethyl)phenylethylideneamine (84984-01-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 81 percent / H₂SO₄ / 2 h / Heating

2: 80 percent / lithium aluminium hydride / diethyl ether / 1 h

3: 67 percent / anh. Na₂CO₃ / ethanol / 18 h / Heating

4: H₂, cc. HCl / 10percent Pd-C / methanol / 4045.3 Torr

5: 89 percent / diethyl ether / 1 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; hydrogen; sodium carbonate; palladium on activated charcoal; In methanol; diethyl ether; ethanol;

DOI:10.1248/cpb.30.3160

upstream raw materials:

(S)-valinol

phenylacetaldehyde

ethyl 2-bromoisovalerate

2-bromoisovaleric acid

Downstream raw materials:

(1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-methoxyphenyl)-2-phenylethylamine

(1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-tolyl)-2-phenylethylamine

(1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1,2-diphenylethylamine hydrochloride

(1R,1'S)-(+)-N-(2'-hydroxy-1'-isopropylethyl)-1-(p-tolyl)-2-phenylethylamine hydrochloride