4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine

Base Information

Chemical Name:4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine
CAS No.:1445385-02-3
Molecular Formula:C₁₈H₂₅ClFN₃O₆
Molecular Weight:433.864
Hs Code.:

Synonyms:

Suppliers and Price of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
ALS-8176 >98%
250 mg
$ 1600.00

Crysdot
ALS-8176 98+%
100mg
$ 1459.00

Crysdot
ALS-8176 98+%
10mg
$ 347.00

Crysdot
ALS-8176 98+%
5mg
$ 243.00

Crysdot
ALS-8176 98+%
50mg
$ 1042.00

ChemScene
Lumicitabine 99.78%
10mg
$ 600.00

ChemScene
Lumicitabine 99.78%
5mg
$ 420.00

ChemScene
Lumicitabine 99.78%
1mg
$ 180.00

ChemScene
Lumicitabine 99.78%
100mg
$ 2520.00

ChemScene
Lumicitabine 99.78%
50mg
$ 1800.00

Total 13 raw suppliers

Chemical Property of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine

Chemical Property:

Boiling Point:533.5±60.0 °C(Predicted)
Density:1.43±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

ALS-8176 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine

There total 15 articles about 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1445385-00-1
C₃₈H₄₁ClFN₃O₇

: 1445385-02-3
4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine

Guidance literature:: With formic acid; In water; at 36 ℃; for 3h;

Reference yield:

: C₁₆H₂₅FN₂O₆Si

: 1445385-02-3
4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine

Guidance literature:: Multi-step reaction with 11 steps

1: sodium tetrahydroborate / ethanol / 0.5 h / 20 °C

2: pyridine / dichloromethane / 14 h / 20 °C

3: 1H-imidazole / dichloromethane / 20 °C

4: acetic acid / 15 h / 20 °C

5: triphenylphosphine; tetrachloromethane / 1,2-dichloro-ethane / 0.67 h / 130 °C / Microwave irradiation; Inert atmosphere

6: triethylamine; dmap / acetonitrile / 20 °C

7: ammonium hydroxide / acetonitrile / 2 h / 20 °C

8: silver nitrate; 2,4,6-trimethyl-pyridine / dichloromethane / 20 °C

9: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

10: pyridine / 20 °C

11: formic acid / 3 h / 35 - 40 °C

With pyridine; 1H-imidazole; 2,4,6-trimethyl-pyridine; tetrachloromethane; dmap; ammonium hydroxide; sodium tetrahydroborate; formic acid; tetrabutyl ammonium fluoride; silver nitrate; acetic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm5017279

Reference yield:

: C₄₇H₆₆ClFN₂O₇SSi₂

: 1445385-02-3
4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide / acetonitrile / 2 h / 20 °C

2: silver nitrate; 2,4,6-trimethyl-pyridine / dichloromethane / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: pyridine / 20 °C

5: formic acid / 3 h / 35 - 40 °C

With pyridine; 2,4,6-trimethyl-pyridine; ammonium hydroxide; formic acid; tetrabutyl ammonium fluoride; silver nitrate; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm5017279