Technology Process of 3-(4-methanesulfonyl-benzyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester
There total 7 articles about 3-(4-methanesulfonyl-benzyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
2: tetrahydrofuran
3: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl
4: sodium hydroxide / methanol / 20 °C
5: hydrogen; 10% Pd/C
6: potassium carbonate / methanol
With
10% Pd/C; hydrogen; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
tetrahydrofuran; methanol;
4: |Aldol Condensation;
DOI:10.1016/j.bmcl.2012.10.066
- Guidance literature:
-
Multi-step reaction with 4 steps
1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl
2: sodium hydroxide / methanol / 20 °C
3: hydrogen; 10% Pd/C
4: potassium carbonate / methanol
With
10% Pd/C; hydrogen; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide;
In
methanol;
2: |Aldol Condensation;
DOI:10.1016/j.bmcl.2012.10.066
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen; 10% Pd/C
2: potassium carbonate / methanol
With
10% Pd/C; hydrogen; potassium carbonate;
In
methanol;
DOI:10.1016/j.bmcl.2012.10.066
