49667-29-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Chloro-6-methylpyridin-3-yl)ethan-1-one is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of novel drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(2-Chloro-6-methylpyridin-3-yl)ethan-1-one is utilized as a building block for the creation of new agrochemicals, which can enhance crop protection and yield.
Used in Dye and Pigment Production:
1-(2-Chloro-6-methylpyridin-3-yl)ethan-1-one is employed as an intermediate in the production of dyes and pigments, where its unique structure contributes to the color and stability of the final products.
Used in Specialty Chemicals Manufacturing:
1-(2-Chloro-6-methylpyridin-3-yl)ethan-1-one also serves as a crucial intermediate in the manufacturing of specialty chemicals, which have specific applications in various industries due to their unique properties.
Safety Note:
It is important to handle 1-(2-Chloro-6-methylpyridin-3-yl)ethan-1-one with care, as it is considered harmful if swallowed. Adequate safety measures should be taken to minimize exposure and prevent adverse health effects.

Upstream product

• 30529-70-5 2-chloro-6-methyl nicotinic acid 
• 1057667-23-8 2-chloro-N-methoxy-N,6-dimethylpyridine-3-carboxyamide 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 1080675-78-0 1-[6-methyl-2-(3-nitrophenylamino)-pyridin-3-yl]-ethanone 
• 1080675-02-0 1-(6-methyl-2-phenylamino-pyridin-3-yl)-ethanone 
• 1421757-18-7 C₂₂H₂₀N₂O₃S 
• 1415591-26-2 C₂₂H₂₂N₂O₃S 
• 1080673-69-3 3-(4-methanesulfonyl-benzyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester 
• 1080673-91-1 3-[4-(2-hydroxy-ethylcarbamoyl)-benzyl]-7-methyl-4-oxo-1-phenyl-1,4-dihydro-[1,8]-naphthyridine-2-carboxylic acid methyl ester 
• 1080674-34-5 7-methyl-4-oxo-1-phenyl-3-[4-(piperazine-1-sulfonyl)benzyl]-1,4-dihydro[1,8]-naphthyridine-2-carboxylic acid methyl ester 
• 1415591-27-3 C₂₅H₂₃N₃O₅S 

Relevant academic research and scientific papers

Discovery of a novel series of 4-quinolone JNK inhibitors

A novel series of highly selective JNK inhibitors based on the 4-quinolone scaffold was designed and synthesized. Structure based drug design was utilized to guide the compound design as well as improvements in the physicochemical properties of the series. Compound (13c) has an IC50 of 62/170 nM for JNK1/2, excellent kinase selectivity and impressive efficacy in a rodent asthma model.

Dihydroquinone and dihydronaphthridine inhibitors of JNK

Compounds of formula I are effective modulators of JNK: wherein X is CR11 or N;Y is —C(O)R3, 5-membered heteroaryl, or 5-membered heterocyclyl;Z is phenyl, cycloalkyl, heterocyclyl or heteroaryl, and is substituted with R1 and R2;R1 and R2 are each independently H, halo, CN, lower alkyl, or —Y1—Y2—Y3—R8, or R1 and R2 together form —O(CH2)nO—, where n is 1 or 2; Y1 is —O—, —C(O)—, —C(O)O—, —C(O)NR9—, —NR9C(O)—, —S—, —SO2—, or a bond;Y2 is cycloalkylene, heterocycloalkylene, lower alkylene or a bond;Y3 is —O—, —C(O)—, —C(O)O—, —C(O)NR9—, —NR9C(O)—, —SO2—, or a bond;R8 is H, lower alkyl, lower alkoxy, cycloalkyl, heterocycloalkyl, or —NR9R10, wherein R8 other than H is optionally substituted with lower alkyl, halo, —CF3, or —OH; R9 and R10 are each independently H or lower alkyl;R3 is OH, lower alkyl, lower alkoxy, (lower alkoxy)-lower alkoxy, or —NR9R10;R4 is lower alkyl, phenyl, heterocyclyl, cycloalkyl, heterocycloalkyl, or heteroaryl, and is optionally substituted with lower alkyl, hydroxy, lower alkoxy, halo, nitro, amino, cyano, or halo-lower alkyl;R5 and R6 are each independently H, halo, cyano, lower alkyl, —CF3, lower alkoxy, —OCHF2, —NO2, or —NR9R10;R7 is H, F, Cl, methyl, or OH;R11 is H, lower alkyl, lower cycloalkyl, or phenyl;or a pharmaceutically acceptable salt thereof.