4-methyl-N-[(1R)-2-{[(1S,2S)-2-{[(2R)-2-(4-methylbenzenesulfonamido)-2-phenylethyl]amino}-1,2-diphenylethy]amino}-1-phenylethyl]benzene-1-sulfonamido

Base Information

• Chemical Name: 4-methyl-N-[(1R)-2-{[(1S,2S)-2-{[(2R)-2-(4-methylbenzenesulfonamido)-2-phenylethyl]amino}-1,2-diphenylethy]amino}-1-phenylethyl]benzene-1-sulfonamido
• CAS No.: 1244040-50-3
• Molecular Formula: C₄₄H₄₆N₄O₄S₂
• Molecular Weight: 759.006

Synonyms:

Chemical Property of 4-methyl-N-[(1R)-2-{[(1S,2S)-2-{[(2R)-2-(4-methylbenzenesulfonamido)-2-phenylethyl]amino}-1,2-diphenylethy]amino}-1-phenylethyl]benzene-1-sulfonamido

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Technology Process of 4-methyl-N-[(1R)-2-{[(1S,2S)-2-{[(2R)-2-(4-methylbenzenesulfonamido)-2-phenylethyl]amino}-1,2-diphenylethy]amino}-1-phenylethyl]benzene-1-sulfonamido

There total 4 articles about 4-methyl-N-[(1R)-2-{[(1S,2S)-2-{[(2R)-2-(4-methylbenzenesulfonamido)-2-phenylethyl]amino}-1,2-diphenylethy]amino}-1-phenylethyl]benzene-1-sulfonamido which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S,S)-1,2-diphenyl-1,2-diaminoethane (29841-69-8) + (R)-2-phenyl-N-tosylaziridine (24395-14-0,149769-84-6,151003-26-8,62596-62-7) → 4-methyl-N-[(1R)-2-{[(1S,2S)-2-{[(2R)-2-(4-methylbenzenesulfonamido)-2-phenylethyl]amino}-1,2-diphenylethy]amino}-1-phenylethyl]benzene-1-sulfonamido (1244040-50-3)

Guidance literature:

In acetonitrile; Reflux;

DOI:10.1002/chem.201900815

Reference yield:

D-2-phenylglycinol (56613-80-0) → 4-methyl-N-[(1R)-2-{[(1S,2S)-2-{[(2R)-2-(4-methylbenzenesulfonamido)-2-phenylethyl]amino}-1,2-diphenylethy]amino}-1-phenylethyl]benzene-1-sulfonamido (1244040-50-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 24 h / 20 °C

2: acetonitrile / 72 h / Reflux

With potassium carbonate; In acetonitrile;

DOI:10.1021/jo101932a

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-methyl-N-[(1R)-2-{[(1S,2S)-2-{[(2R)-2-(4-methylbenzenesulfonamido)-2-phenylethyl]amino}-1,2-diphenylethy]amino}-1-phenylethyl]benzene-1-sulfonamido (1244040-50-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 24 h / 20 °C

2: acetonitrile / 72 h / Reflux

With potassium carbonate; In acetonitrile;

DOI:10.1021/jo101932a

upstream raw materials:

(S,S)-1,2-diphenyl-1,2-diaminoethane

(R)-2-phenyl-N-tosylaziridine

D-2-phenylglycinol

p-toluenesulfonyl chloride

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