(2S)-1-(4-methylphenyl)sulfonyl-2-phenylaziridine

Base Information

• Chemical Name: (2S)-1-(4-methylphenyl)sulfonyl-2-phenylaziridine
• CAS No.: 24395-14-0
• Molecular Formula: C15H15 N O2 S
• Molecular Weight: 273.356
• DSSTox Substance ID: DTXSID60947265
• Nikkaji Number: J623.926I
• Mol file: 24395-14-0.mol

Synonyms:149769-84-6;(2S)-1-(4-methylphenyl)sulfonyl-2-phenylaziridine;(S)-2-Phenyl-1-tosylaziridine;(2S)-1-Tosyl-2-phenylaziridine;S-1-[(4-Methylphenyl)sulfonyl]-2--phenyl-Aziridine;Aziridine, 1-[(4-methylphenyl)sulfonyl]-2-phenyl-, (2S)-;SCHEMBL17970866;DTXSID60947265;1-(4-Methylbenzene-1-sulfonyl)-2-phenylaziridine;(2S)-1-(4-METHYLBENZENESULFONYL)-2-PHENYLAZIRIDINE

Chemical Property of (2S)-1-(4-methylphenyl)sulfonyl-2-phenylaziridine

Chemical Property:

• Vapor Pressure: 1.43E-07mmHg at 25°C
• Boiling Point: 429.2°Cat760mmHg
• Flash Point: 213.4°C
• Density: 1.289g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 273.08234989
• Heavy Atom Count: 19
• Complexity: 400

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)N2CC2C3=CC=CC=C3
• Isomeric SMILES: CC1=CC=C(C=C1)S(=O)(=O)N2C[C@@H]2C3=CC=CC=C3

Technology Process of (2S)-1-(4-methylphenyl)sulfonyl-2-phenylaziridine

There total 146 articles about (2S)-1-(4-methylphenyl)sulfonyl-2-phenylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + [N-(p-tolylsulfonyl)imino]phenyliodinane (55962-05-5) → N-(p-tolylsulfonyl)-2-phenylaziridine (24395-14-0)

Guidance literature:

With [CuI(tris[(tetramethylguanidino)-phenyl]amine)][PF₆]; In acetonitrile; for 2h; Inert atmosphere; Molecular sieve;

DOI:10.1021/ja503869j

Reference yield: 99.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + toluene-4-sulfonamide (70-55-3) → N-(p-tolylsulfonyl)-2-phenylaziridine (24395-14-0)

Guidance literature:

With copper(l) iodide; iodosylbenzene; In acetonitrile; at 20 ℃; for 18h; Molecular sieve; Inert atmosphere;

DOI:10.1016/j.tetlet.2008.10.105

Reference yield: 97.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + chloroamine-T (127-65-1) → N-(p-tolylsulfonyl)-2-phenylaziridine (24395-14-0)

Guidance literature:

With iodine; benzyltriethylammonium bromide; at 20 ℃; for 1h;

DOI:10.1039/b104940m

upstream raw materials:

styrene

N,N-dichloro-p-toluenesulfonamide

[N-(p-tolylsulfonyl)imino]phenyliodinane

N-(2-bromo-1-phenylethyl)-4-methylbenzenesulfonamide

Downstream raw materials:

N-(3-Methanesulfinyl-1-phenyl-propyl)-4-methyl-benzenesulfonamide

(+/-)-N-(2-cyano-1-phenyl-ethyl)-4-methyl-benzene sulfonamide

3-Methyl-1a-phenyl-1,1a,1b,5a-tetrahydro-6-thia-6a-aza-cyclopropa[a]indene 6,6-dioxide

3-phenyl-1-tosylazetidine