2-Benzoyl-1H-indole

Base Information

• Chemical Name: 2-Benzoyl-1H-indole
• CAS No.: 1022-86-2
• Molecular Formula: C15H11NO
• Molecular Weight: 221.258
• Hs Code.: 2933990090
• Mol file: 1022-86-2.mol

Synonyms:Indole,2-benzoyl;2-Benzoyl-1H-indole;1H-2-indolyl-phenyl-methanone;2-Benzoylindole;

Chemical Property of 2-Benzoyl-1H-indole

Chemical Property:

• Melting Point: 144-145 °C
• Boiling Point: 422.1±18.0 °C(Predicted)
• PKA: 15.10±0.30(Predicted)
• PSA: 32.86000
• Density: 1.229±0.06 g/cm3(Predicted)
• LogP: 3.39890

Purity/Quality:

98%,99%, ^*data from raw suppliers

1H-INDOL-2-YLPHENYL-METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Benzoyl-1H-indole

There total 110 articles about 2-Benzoyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridin-2-yl 1H-indole-2-carboxylate + phenylboronic acid (98-80-6) → 2-benzoylindole (1022-86-2)

Guidance literature:

With potassium phosphate; Pd/α-Al2O3; palladium; In water; toluene; at 120 ℃; for 48h; chemoselective reaction;

DOI:10.1039/c9ra02394a

Reference yield: 95.7%

phenylglyoxal hydrate (1074-12-0) + 2-aminophenylacetonitrile (2973-50-4) → 2-benzoylindole (1022-86-2)

Guidance literature:

With 1-(diphenylphosphino)ferrocene-1-(di-tert-butylphosphino)ferrocene; 1-cyanopropyl-3-methylimidazolium tetrafluoroborate; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; tin(IV) iodide; cerium triflate; In ethylene glycol; at 80 ℃; for 12h; Reagent/catalyst; Catalytic behavior;

Reference yield: 95.0%

phenylzinc(II) bromide (38111-44-3) + S-phenyl 1H-indole-2-carbothioate → 2-benzoylindole (1022-86-2)

Guidance literature:

With (phenyl)(bis-triphenylphosphine)palladium(II) chloride; In tetrahydrofuran; toluene; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00031

upstream raw materials:

benzoic acid methyl ester

2-benzoyl-1H-indole-3-carboxylic acid

(E)-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one

1-phenacylindole-2,3-dione

Downstream raw materials:

(1H-Indol-2-yl)-phenyl-methanone oxime

(1H-indol-2-yl)phenylmethanone oxime

(1-methyl-1H-indol-2-yl)(phenyl)methanone

phenyl(1-prop-2-ynyl-1H-indol-2-yl)methanone