methyl 3-(5-((2-iodophenyl)(methyl)amino)-2-methyloxazol-4-yl)propanoate

Base Information

• Chemical Name: methyl 3-(5-((2-iodophenyl)(methyl)amino)-2-methyloxazol-4-yl)propanoate
• CAS No.: 1298035-54-7
• Molecular Formula: C₁₅H₁₇IN₂O₃
• Molecular Weight: 400.216
• Mol file: 1298035-54-7.mol

Synonyms:

Chemical Property of methyl 3-(5-((2-iodophenyl)(methyl)amino)-2-methyloxazol-4-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(5-((2-iodophenyl)(methyl)amino)-2-methyloxazol-4-yl)propanoate

There total 6 articles about methyl 3-(5-((2-iodophenyl)(methyl)amino)-2-methyloxazol-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

methyl 3-(5-(2-iodophenylamino)-2-methyloxazol-4-yl)propanoate (1298035-50-3) + methyl iodide (74-88-4) → methyl 3-(5-((2-iodophenyl)(methyl)amino)-2-methyloxazol-4-yl)propanoate (1298035-54-7)

Guidance literature:

methyl 3-(5-(2-iodophenylamino)-2-methyloxazol-4-yl)propanoate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.333333h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0030-1259302

Reference yield:

methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate (1298035-68-3) → methyl 3-(5-((2-iodophenyl)(methyl)amino)-2-methyloxazol-4-yl)propanoate (1298035-54-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: pyridine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid; trifluoroacetic anhydride / dichloromethane / 36 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With pyridine; sodium hydride; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1055/s-0030-1259302

Reference yield:

C12H15IN2O3 → methyl 3-(5-((2-iodophenyl)(methyl)amino)-2-methyloxazol-4-yl)propanoate (1298035-54-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; trifluoroacetic anhydride / dichloromethane / 36 h / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With pyridine; sodium hydride; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1055/s-0030-1259302

upstream raw materials:

methyl 3-(5-(2-iodophenylamino)-2-methyloxazol-4-yl)propanoate

methyl iodide

methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate

methyl 4-acetamido-5-(2-iodophenylamino)-5-oxopentanoate