3,4,5,6-tetrafluorophthalic acid dimethyl ester

Base Information

• Chemical Name: 3,4,5,6-tetrafluorophthalic acid dimethyl ester
• CAS No.: 1024-59-5
• Molecular Formula: C10H6F4O4
• Molecular Weight: 266.149
• Hs Code.: 2917399090
• Mol file: 1024-59-5.mol

Synonyms:dimethyl tetrafluorophthalate;3,4,5,6-Tetrafluor-phthalsaeure-dimethylester;1,2,3,4-Tetrafluorphthalsaeuredimethylester;3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid,dimethyl ester;HMS1578G15;Phthalic acid,tetrafluoro-,dimethyl ester;tetrafluorobenzene-o-dicarboxylic acid dimethyl ester;Dimethyl 3,4,5,6-tetrafluorophthalate;

Chemical Property of 3,4,5,6-tetrafluorophthalic acid dimethyl ester

Chemical Property:

• PSA: 52.60000
• LogP: 1.81620

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4,5,6-tetrafluorophthalic acid dimethyl ester

There total 8 articles about 3,4,5,6-tetrafluorophthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

sulfolane (126-33-0,208252-54-4) + hexachloro-phthalide (34973-43-8) → 3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid,dimethyl ester (1024-59-5)

Guidance literature:

With hydrogenchloride; potassium fluoride; triethylamine; In methanol; n-heptane; water; toluene;

Reference yield:

3,4,5,6-tetrafluorophthalic acid (652-03-9) → 3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid,dimethyl ester (1024-59-5)

Guidance literature:

In methanol; sulfuric acid;

Reference yield:

tetrafluorothiophene S,S-dioxide (1507363-73-6) + dimethyl acetylenedicarboxylate (762-42-5) → 3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid,dimethyl ester (1024-59-5)

Guidance literature:

In toluene; at 100 ℃; for 17h;

DOI:10.1021/acs.joc.6b00848

upstream raw materials:

1,2-dibromo-3,4,5,6-tetrafluorobenzene

carbonic acid dimethyl ester

3,4,5,6-tetrafluorophthalic acid

sulfolane

Downstream raw materials:

3,4,5,6-tetrafluorophthalic acid

dimethyl 4-(1,1-bis-ethoxycarbonylethyl)-3,5,6-trifluorophthalate

dimethyl 4-diethoxycarbonylmethyl-3,5,6-trifluorophthalate

dimethyl 3,5,6-trifluoro-4-nitromethylphthalate

Refernces

• 1、 Colomban, Cédric,Kudrik, Evgenij V.,Afanasiev, Pavel,Sorokin, Alexander B.. "Catalytic defluorination of perfluorinated aromatics under oxidative conditions using N-bridged diiron phthalocyanine". supporting information. p. 11321 - 11330. Retrieved 2014/11/07.
• 2、 Lemal, David M.,Ramanathan, Sudharsanam,Shellito, John. "o-fluoranil chemistry: Diels-Alder versus hetero-Diels-Alder cycloaddition". . p. 3392 - 3396. Retrieved 2008/09/21.