PEG13-Tos

Base Information

• Chemical Name: PEG13-Tos
• CAS No.: 1050500-41-8
• Molecular Formula: C₃₁H₅₆O₁₅S
• Molecular Weight: 700.843
• Mol file: 1050500-41-8.mol

Synonyms:

Chemical Property of PEG13-Tos

Chemical Property:

Purity/Quality:

98.0% ^*data from raw suppliers

PEG13-tos ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: PEG13-Tos is a PEG linker containing a hydroxyl group and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
• Uses: PEG13-tos is a cross linker in the synthesis antibody-drug conjugates.

Technology Process of PEG13-Tos

There total 1 articles about PEG13-Tos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

dodecaethylene glycol (6790-09-6) + p-toluenesulfonyl chloride (98-59-9) → dodecaethylene glycol mono(p-toluene-sulphonate) ester (1050500-41-8)

Guidance literature:

With potassium iodide; silver(l) oxide; In chloroform; for 0.166667h;

DOI:10.1021/ol701925a

Reference yield: 82.0%

dodecaethylene glycol mono(p-toluene-sulphonate) ester (1050500-41-8) + p-toluenesulfonyl chloride (98-59-9) → 3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane-1,35-diyl bis(4-methylbenzenesulfonate) (1456708-45-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 25h;

DOI:10.1021/jacs.0c09470

upstream raw materials:

dodecaethylene glycol

p-toluenesulfonyl chloride

Downstream raw materials:

3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane-1,35-diyl bis(4-methylbenzenesulfonate)