Tos-PEG13-Tos

Base Information

• Chemical Name: Tos-PEG13-Tos
• CAS No.: 1456708-45-4
• Molecular Formula: C₃₈H₆₂O₁₇S₂
• Molecular Weight: 855.032
• Mol file: 1456708-45-4.mol

Synonyms:

Chemical Property of Tos-PEG13-Tos

Chemical Property:

Purity/Quality:

>95.00% ^*data from raw suppliers

Tos-PEG13-Tos ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Tos-PEG13-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Technology Process of Tos-PEG13-Tos

There total 7 articles about Tos-PEG13-Tos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dodecaethylene glycol (6790-09-6) + p-toluenesulfonyl chloride (98-59-9) → 3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane-1,35-diyl bis(4-methylbenzenesulfonate) (1456708-45-4)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/b924631b

Reference yield: 94.0%

p-toluenesulfonyl chloride (98-59-9) + 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol (6809-70-7) → 3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane-1,35-diyl bis(4-methylbenzenesulfonate) (1456708-45-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 3h; Cooling with ice;

Reference yield: 82.0%

dodecaethylene glycol mono(p-toluene-sulphonate) ester (1050500-41-8) + p-toluenesulfonyl chloride (98-59-9) → 3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane-1,35-diyl bis(4-methylbenzenesulfonate) (1456708-45-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 25h;

DOI:10.1021/jacs.0c09470

upstream raw materials:

dodecaethylene glycol

p-toluenesulfonyl chloride

tetraethylene glycol di(p-toluenesulfonate)

Tetraethylene glycol