(2′S,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

Base Information

• Chemical Name: (2′S,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid
• CAS No.: 1375747-12-8
• Molecular Formula: C₂HF₃O₂*C₂₅H₂₉Cl₂N₃O₂
• Molecular Weight: 588.454

Synonyms:

Chemical Property of (2′S,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2′S,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

There total 4 articles about (2′S,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-2'-(2,2-dimethylpropyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide (860797-95-1) + trifluoroacetic acid (76-05-1) → (2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid (1375747-11-7) + (2′S,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid (1375747-12-8) + (2′R,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid (1432582-36-9) + (2'S,3S,4'R,5'R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide (1432582-09-6)

Guidance literature:

(1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-2'-(2,2-dimethylpropyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide; With ammonium cerium (IV) nitrate; In water; acetonitrile; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; acetonitrile; at 20 ℃; for 72h; pH=8;

trifluoroacetic acid; In water; acetonitrile;

DOI:10.1021/ja3125417

Reference yield:

C37H34Cl2N2O3 (897365-77-4) → (2′S,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid (1375747-12-8) + (2′R,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid (1432582-36-9) + (2'S,3S,4'R,5'R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide (1432582-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 20 °C

2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 1 h / 20 °C

2.2: 72 h / 20 °C / pH 8

With ammonium cerium (IV) nitrate; In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/ja3125417

Reference yield:

E/Z-6-chloro-3-[1-(3-chlorophenyl)methylidene]-1,3-dihydroindol-2-one (387344-30-1) → (2′S,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid (1375747-12-8) + (2′R,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid (1432582-36-9) + (2'S,3S,4'R,5'R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide (1432582-09-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 70 °C / Molecular sieve

2.1: tetrahydrofuran / 20 °C

3.1: ammonium cerium (IV) nitrate / acetonitrile; water / 1 h / 20 °C

3.2: 72 h / 20 °C / pH 8

With ammonium cerium (IV) nitrate; In tetrahydrofuran; water; toluene; acetonitrile;

DOI:10.1021/ja3125417

upstream raw materials:

E/Z-6-chloro-3-[1-(3-chlorophenyl)methylidene]-1,3-dihydroindol-2-one

pivalaldehyde

C₃₇H₃₄Cl₂N₂O₃

(1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-2'-(2,2-dimethylpropyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1375747-12-8 (2′S,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send