860797-95-1

Upstream product

• 897365-77-4 C₃₇H₃₄Cl₂N₂O₃ 
• 124-40-3 dimethyl amine 
• 860798-06-7 6-chloro-3-[1-(3-chloro-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one 
• 630-19-3 pivalaldehyde 
• 387344-30-1 E/Z-6-chloro-3-[1-(3-chlorophenyl)methylidene]-1,3-dihydroindol-2-one 
• 2987-16-8 3,3-dimethylbutyrylaldehyde 
• 282735-66-4 (5R,6S)-5,6-diphenylmorpholin-2-one 
• 56341-37-8 6-chloro-2-oxindole 
• 587-04-2 m-Chlorobenzaldehyde 

Downstream Products

• 1375747-11-7 (2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid 
• 1375747-12-8 (2′S,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid 
• 1432582-36-9 (2′R,3R,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid 
• 1432582-09-6 (2'S,3S,4'R,5'R)-6-chloro-4′-(3-chlorophenyl)-N,N-dimethyl-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide 

Relevant academic research and scientific papers

Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors

Small-molecule inhibitors that block the MDM2-p53 protein-protein interaction (MDM2 inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We previously published a series of spirooxindole-containing compounds as a new

SPIRO-OXINDOLE MDM2 ANTAGONISTS

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as

SMALL MOLECULE INHIBITORS OF MDM2 AND USES THEREOF

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sens

Structure-based design of potent non-peptide MDM2 inhibitors

A successful structure-based design of a class of non-peptide small-molecule MDM2 inhibitors targeting the p53-MDM2 protein-protein interaction is reported. The most potent compound 1d binds to MDM2 protein with a Ki value of 86 nM and is 18 ti