(4S)-9-(Acetyloxy)-10-[(acetyloxy)Methyl]-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Base Information

• Chemical Name: (4S)-9-(Acetyloxy)-10-[(acetyloxy)Methyl]-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• CAS No.: 1304788-26-8
• Molecular Formula: C₂₅H₂₂N₂O₈
• Molecular Weight: 478.458
• Mol file: 1304788-26-8.mol

Synonyms:

Chemical Property of (4S)-9-(Acetyloxy)-10-[(acetyloxy)Methyl]-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Chemical Property:

• Solubility.: DMSO, Methanol, Water

Purity/Quality:

(4S)-9-(Acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-4-hydroxy-1H-pyrano[3'',4'':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (4S)-9-(Acetyloxy)-10-[(acetyloxy)methyl]-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione is an intermediate in the synthesis of Camptothecin analogs for the inhibition of topoisomerase I and antitumor activity.

Technology Process of (4S)-9-(Acetyloxy)-10-[(acetyloxy)Methyl]-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

There total 2 articles about (4S)-9-(Acetyloxy)-10-[(acetyloxy)Methyl]-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.2%

acetic anhydride (108-24-7) + topotecan (123948-87-8) → 10-acetoxy-9-acetoxymethyl-(20S)-camptothecin (1304788-26-8)

Guidance literature:

at 50 ℃; for 49h;

DOI:10.1016/j.bmcl.2011.02.080

Reference yield: 8.67%

acetic anhydride (108-24-7) + topotecan (123948-87-8) → 10-acetoxy-9-acetoxymethyl-(20S)-camptothecin (1304788-26-8) + 10,20(S)-diacetoxy-9-acetoxymethyl-(20S)-camptothecin (1304788-27-9)

Guidance literature:

With dmap; In chloroform; Reflux;

DOI:10.1016/j.bmcl.2011.02.080

upstream raw materials:

acetic anhydride

topotecan