Technology Process of SITC-dUTP
There total 4 articles about SITC-dUTP which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triphenylphosphine / chloroform / 1.5 h / 20 °C
2: water; dimethyl sulfoxide / 6 h / 20 °C
With
triphenylphosphine;
In
chloroform; water; dimethyl sulfoxide;
DOI:10.1039/c2cc32038j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: naphthalene; lithium / tetrahydrofuran / 1.07 h / 20 °C
1.2: 1 h / 0 - 20 °C
1.3: Reflux
2.1: triphenylphosphine / chloroform / 1.5 h / 20 °C
3.1: water; dimethyl sulfoxide / 6 h / 20 °C
With
naphthalene; lithium; triphenylphosphine;
In
tetrahydrofuran; chloroform; water; dimethyl sulfoxide;
DOI:10.1039/c2cc32038j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium azide / dimethyl sulfoxide / 12 h / 70 °C
2.1: naphthalene; lithium / tetrahydrofuran / 1.07 h / 20 °C
2.2: 1 h / 0 - 20 °C
2.3: Reflux
3.1: triphenylphosphine / chloroform / 1.5 h / 20 °C
4.1: water; dimethyl sulfoxide / 6 h / 20 °C
With
sodium azide; naphthalene; lithium; triphenylphosphine;
In
tetrahydrofuran; chloroform; water; dimethyl sulfoxide;
DOI:10.1039/c2cc32038j