tert-butyl (2S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-L-prolinate

Base Information

Chemical Name:tert-butyl (2S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-L-prolinate
CAS No.:1033708-07-4
Molecular Formula:C₃₁H₃₅Cl₂N₃O₃S
Molecular Weight:600.609
Hs Code.:

Synonyms:

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Chemical Property of tert-butyl (2S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-L-prolinate

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Technology Process of tert-butyl (2S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-L-prolinate

There total 7 articles about tert-butyl (2S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-L-prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1033707-10-6
(4S,5R)-4,5-bis(4-chlorophenyl)-4-methylimidazolidine-2-thione

: 1033708-07-4
tert-butyl (2S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-L-prolinate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / Reflux

2: sodium hydroxide / water; ethanol / 60 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.091

Reference yield:

: 1033707-12-8
Ethyl (5R,6S)-5,6-Bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylate

: 1033708-07-4
tert-butyl (2S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-L-prolinate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; ethanol / 60 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.091

Reference yield:

: (1R*,2S*)-1,2-bis(4-chlorophenyl)propane-1,2-diamine

: 1033708-07-4
tert-butyl (2S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-L-prolinate

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / Reflux

2: sodium hydroxide / water

3: ethanol / Reflux

4: ethanol / Reflux

5: sodium hydroxide / water; ethanol / 60 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.091