6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-8-((E)-phenyldiazenyl)-4H-chromen-4-one

Base Information

• Chemical Name: 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-8-((E)-phenyldiazenyl)-4H-chromen-4-one
• CAS No.: 1373132-44-5
• Molecular Formula: C₂₆H₁₉BrN₂O₅
• Molecular Weight: 519.351
• Mol file: 1373132-44-5.mol

Synonyms:

Chemical Property of 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-8-((E)-phenyldiazenyl)-4H-chromen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-8-((E)-phenyldiazenyl)-4H-chromen-4-one

There total 3 articles about 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-8-((E)-phenyldiazenyl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one (1373132-40-1) + aniline (62-53-3) → 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-8-((E)-phenyldiazenyl)-4H-chromen-4-one (1373132-44-5)

Guidance literature:

aniline; With hydrogenchloride; sodium nitrite; In water; for 0.5h; Cooling with ice;

6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one; With sodium hydroxide; In ethanol; for 1h; Cooling with ice;

DOI:10.1248/cpb.60.110

Reference yield:

7-hydroxy-5-methoxy-2-methyl-4-oxo-4H-chromene-6-carbaldehyde (7338-51-4) → 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-8-((E)-phenyldiazenyl)-4H-chromen-4-one (1373132-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 24 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0.5 h / Cooling with ice

2.2: 1 h / Cooling with ice

With hydrogenchloride; sodium hydroxide; sodium nitrite; In ethanol; water; 1.1: Claisen Schmidt condensation;

DOI:10.1248/cpb.60.110

Reference yield:

visnagin (82-57-5) → 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-8-((E)-phenyldiazenyl)-4H-chromen-4-one (1373132-44-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium dichromate; sulfuric acid / 0.5 h / 20 - 80 °C

2.1: sodium hydroxide / ethanol / 24 h / 20 °C

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / Cooling with ice

3.2: 1 h / Cooling with ice

With hydrogenchloride; potassium dichromate; sulfuric acid; sodium hydroxide; sodium nitrite; In ethanol; water; 2.1: Claisen Schmidt condensation;

DOI:10.1248/cpb.60.110

upstream raw materials:

7-hydroxy-5-methoxy-2-methyl-4-oxo-4H-chromene-6-carbaldehyde

6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one

aniline

visnagin

Downstream raw materials:

(E)-8-amino-6-(4-bromophenyl-3-oxoprop-1-enyl)-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one