6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one

Base Information

• Chemical Name: 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one
• CAS No.: 1373132-40-1
• Molecular Formula: C₂₀H₁₅BrO₅
• Molecular Weight: 415.24
• Mol file: 1373132-40-1.mol

Synonyms:6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one

Chemical Property of 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one

There total 2 articles about 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

7-hydroxy-5-methoxy-2-methyl-4-oxo-4H-chromene-6-carbaldehyde (7338-51-4) + para-bromoacetophenone (99-90-1) → 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one (1373132-40-1)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 24h;

DOI:10.1248/cpb.60.110

Reference yield:

visnagin (82-57-5) → 6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one (1373132-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium dichromate; sulfuric acid / 0.5 h / 20 - 80 °C

2: sodium hydroxide / ethanol / 24 h / 20 °C

With potassium dichromate; sulfuric acid; sodium hydroxide; In ethanol; 2: Claisen Schmidt condensation;

DOI:10.1248/cpb.60.110

Reference yield: 60.0%

6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one (1373132-40-1) + thiourea (17356-08-0) → C21H17BrN2O4S (1373132-50-3)

Guidance literature:

With sulfuric acid; In N,N-dimethyl-formamide; for 6h; Reflux;

DOI:10.1248/cpb.60.110

upstream raw materials:

7-hydroxy-5-methoxy-2-methyl-4-oxo-4H-chromene-6-carbaldehyde

para-bromoacetophenone

visnagin

Downstream raw materials:

(E)-8-amino-6-(4-bromophenyl-3-oxoprop-1-enyl)-7-hydroxy-5-methoxy-2-methyl-4H-chromen-4-one

6-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]-7-hydroxy-5-methoxy-2-methyl-8-((E)-phenyldiazenyl)-4H-chromen-4-one

C₂₁H₁₇BrN₂O₄S