1-(((6R,7R)-7-((Z)-2-((((S)-4-(tert-butoxy)-1-((4-methoxybenzyl)oxy)-1,4-dioxobutan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-2-(((4-methoxybenzyl)oxy)carbonyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-(2-(5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxamido)ethyl)pyrrolidin-1-ium

Base Information

• Chemical Name: 1-(((6R,7R)-7-((Z)-2-((((S)-4-(tert-butoxy)-1-((4-methoxybenzyl)oxy)-1,4-dioxobutan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-2-(((4-methoxybenzyl)oxy)carbonyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-(2-(5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxamido)ethyl)pyrrolidin-1-ium
• CAS No.: 1429438-75-4
• Molecular Formula: C₆₃H₇₅N₈O₁₇S₂
• Molecular Weight: 1280.46
• Mol file: 1429438-75-4.mol

Synonyms:

Chemical Property of 1-(((6R,7R)-7-((Z)-2-((((S)-4-(tert-butoxy)-1-((4-methoxybenzyl)oxy)-1,4-dioxobutan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-2-(((4-methoxybenzyl)oxy)carbonyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-(2-(5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxamido)ethyl)pyrrolidin-1-ium

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(((6R,7R)-7-((Z)-2-((((S)-4-(tert-butoxy)-1-((4-methoxybenzyl)oxy)-1,4-dioxobutan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-2-(((4-methoxybenzyl)oxy)carbonyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-(2-(5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxamido)ethyl)pyrrolidin-1-ium

There total 7 articles about 1-(((6R,7R)-7-((Z)-2-((((S)-4-(tert-butoxy)-1-((4-methoxybenzyl)oxy)-1,4-dioxobutan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-2-(((4-methoxybenzyl)oxy)carbonyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-(2-(5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxamido)ethyl)pyrrolidin-1-ium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-tert-butyl 1-(4-methoxybenzyl) 2-(((Z)-(1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-(((6R,7R)-3-(iodomethyl)-2-(((4-methoxybenzyl)oxy)carbonyl)-5-oxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)amino)-2-oxoethylidene)amino)oxy)succinate + 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide (1429438-74-3) → 1-(((6R,7R)-7-((Z)-2-((((S)-4-(tert-butoxy)-1-((4-methoxybenzyl)oxy)-1,4-dioxobutan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-2-(((4-methoxybenzyl)oxy)carbonyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-(2-(5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxamido)ethyl)pyrrolidin-1-ium (1429438-75-4)

Guidance literature:

(S)-4-tert-butyl 1-(4-methoxybenzyl) 2-(((Z)-(1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-(((6R,7R)-3-(iodomethyl)-2-(((4-methoxybenzyl)oxy)carbonyl)-5-oxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)amino)-2-oxoethylidene)amino)oxy)succinate; 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide; In N,N-dimethyl acetamide; at 40 ℃; for 3h; Inert atmosphere;

With phosphorus tribromide; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; at -40 ℃; for 0.666667h; Inert atmosphere;

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 1-(((6R,7R)-7-((Z)-2-((((S)-4-(tert-butoxy)-1-((4-methoxybenzyl)oxy)-1,4-dioxobutan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-2-(((4-methoxybenzyl)oxy)carbonyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-(2-(5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxamido)ethyl)pyrrolidin-1-ium (1429438-75-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.67 h / 0 - 20 °C / Inert atmosphere

1.2: 72.24 h / 50 °C / Inert atmosphere

2.1: pyridine; sulfur trioxide; triethylamine / chloroform; dimethyl sulfoxide / 20 h / 0 - 20 °C / Inert atmosphere

3.1: 20 h / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4.2: 3 h / Inert atmosphere

5.1: N,N-dimethyl acetamide / 3 h / 40 °C / Inert atmosphere

5.2: 0.67 h / -40 °C / Inert atmosphere

With pyridine; sulfur trioxide; potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In chloroform; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

(S)-4-tert-butyl 1-(4-methoxybenzyl) 2-(((Z)-(1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-(((6R,7R)-3-(chloromethyl)-2-(((4-methoxybenzyl)oxy)carbonyl)-5-oxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)amino)-2-oxoethylidene)amino)oxy)succinate (1338730-20-3) → 1-(((6R,7R)-7-((Z)-2-((((S)-4-(tert-butoxy)-1-((4-methoxybenzyl)oxy)-1,4-dioxobutan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-2-(((4-methoxybenzyl)oxy)carbonyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-(2-(5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxamido)ethyl)pyrrolidin-1-ium (1429438-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium iodide / acetone / 2 h / 20 °C / Inert atmosphere

2.1: N,N-dimethyl acetamide / 3 h / 40 °C / Inert atmosphere

2.2: 0.67 h / -40 °C / Inert atmosphere

With sodium iodide; In N,N-dimethyl acetamide; acetone;

upstream raw materials:

p-methoxybenzyl chloride

(S)-4-tert-butyl 1-(4-methoxybenzyl) 2-(((Z)-(1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-(((6R,7R)-3-(chloromethyl)-2-(((4-methoxybenzyl)oxy)carbonyl)-5-oxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)amino)-2-oxoethylidene)amino)oxy)succinate

5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one