5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide

Base Information

Chemical Name:5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide
CAS No.:1429438-74-3
Molecular Formula:C₂₁H₂₇N₃O₄
Molecular Weight:385.463
Hs Code.:

Synonyms:5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide

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Chemical Property of 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide

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Technology Process of 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide

There total 5 articles about 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 1401529-01-8
5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxylic acid

: 1429438-74-3
5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide

Guidance literature:: 5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-1,4-dihydropyridin-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

1-(2-aminoethyl)pyrrolidine; In N,N-dimethyl-formamide; for 3h; Inert atmosphere;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1429438-74-3
5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.67 h / 0 - 20 °C / Inert atmosphere

1.2: 72.24 h / 50 °C / Inert atmosphere

2.1: pyridine; sulfur trioxide; triethylamine / chloroform; dimethyl sulfoxide / 20 h / 0 - 20 °C / Inert atmosphere

3.1: 20 h / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4.2: 3 h / Inert atmosphere

With pyridine; sulfur trioxide; potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 1429438-74-3
5-((4-methoxybenzyl)oxy)-1-methyl-4-oxo-N-(2-(pyrrolidin-1-yl)ethyl)-1,4-dihydropyridin-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.67 h / 0 - 20 °C / Inert atmosphere

1.2: 72.24 h / 50 °C / Inert atmosphere

2.1: pyridine; sulfur trioxide; triethylamine / chloroform; dimethyl sulfoxide / 20 h / 0 - 20 °C / Inert atmosphere

3.1: 20 h / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4.2: 3 h / Inert atmosphere

With pyridine; sulfur trioxide; potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;