Technology Process of 4α-(4-benzyloxybutyl)-5-methyl-3aβ,4β,7,7aβ-tetrahydrophthalide
There total 7 articles about 4α-(4-benzyloxybutyl)-5-methyl-3aβ,4β,7,7aβ-tetrahydrophthalide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
N,N-dimethyl-formamide; toluene;
for 17h;
Ambient temperature;
DOI:10.1248/cpb.39.1359
- Guidance literature:
-
Multi-step reaction with 7 steps
1: PCC / CH2Cl2 / 1.5 h / Ambient temperature
2: toluene / 10 h / 100 °C / bath temp.
3: LiAlH4 / diethyl ether / 0.17 h / ice bath
4: PCC / CH2Cl2
5: 1.) BuLi / 1.) THF, hexane, -5 deg C to r.t., 30 min; 2.) -15 deg C to r.t., 30 min
6: 82.6 percent / toluene / 17 h / 100 °C / bath temp.; hydroquinone for stabilization
7: 23.4 percent / NaBH4 / toluene; dimethylformamide / 17 h / Ambient temperature
With
sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; pyridinium chlorochromate;
In
diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.39.1359
- Guidance literature:
-
Multi-step reaction with 6 steps
1: toluene / 10 h / 100 °C / bath temp.
2: LiAlH4 / diethyl ether / 0.17 h / ice bath
3: PCC / CH2Cl2
4: 1.) BuLi / 1.) THF, hexane, -5 deg C to r.t., 30 min; 2.) -15 deg C to r.t., 30 min
5: 82.6 percent / toluene / 17 h / 100 °C / bath temp.; hydroquinone for stabilization
6: 23.4 percent / NaBH4 / toluene; dimethylformamide / 17 h / Ambient temperature
With
sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; pyridinium chlorochromate;
In
diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.39.1359
