1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide

Base Information

• Chemical Name: 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide
• CAS No.: 1262983-77-6
• Molecular Formula: C₅₃H₃₉FN₈O₇
• Molecular Weight: 918.94

Synonyms:

Chemical Property of 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide

There total 6 articles about 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-bromoethoxyphthalimide (5181-35-1) + 2,6-dimethyl-N3,N5-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide (1262983-73-2) → 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N3,N5-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide (1262983-77-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 12h; Reflux;

Reference yield:

4-(4-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbohydrazide (1262983-67-4) → 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N3,N5-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide (1262983-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / ethanol / 8 h / Reflux

2: triethylamine / N,N-dimethyl-formamide / 12 h / Reflux

With pyridine; triethylamine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N3,N5-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide (1262983-77-6)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonia / ethanol / Reflux

2: hydrazine hydrate / 1,4-dioxane / Reflux

3: pyridine / ethanol / 8 h / Reflux

4: triethylamine / N,N-dimethyl-formamide / 12 h / Reflux

With pyridine; ammonia; hydrazine hydrate; triethylamine; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

phthalic anhydride

4-(4-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbohydrazide

2-bromoethoxyphthalimide

2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide

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