5181-35-1

Usage

InChI:InChI=1/C10H8BrNO3/c11-5-6-15-12-9(13)7-3-1-2-4-8(7)10(12)14/h1-4H,5-6H2

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 106-93-4 ethylene dibromide 
• 85-44-9 phthalic anhydride 
• 107-04-0 1-Bromo-2-chloroethane 
• 540-51-2 2-bromoethanol 

Downstream Products

• 847021-05-0 2-(2-{4-Oxo-2-[(E)-phenylimino]-5-[1-phenyl-meth-(Z)-ylidene]-thiazolidin-3-yl}-ethoxy)-isoindole-1,3-dione 
• 847020-96-6 2-(2-{4-Oxo-2-[(E)-phenylimino]-thiazolidin-3-yl}-ethoxy)-isoindole-1,3-dione 
• 1184724-93-3 C₂₃H₂₂N₄O₄ 
• 947339-36-8 C₂₁H₁₇N₃O₄ 
• 947339-33-5 C₂₁H₁₆ClN₃O₄ 
• 947339-30-2 C₂₂H₁₉N₃O₅ 
• 1228386-54-6 C₃₂H₂₂ClN₅O₅S 
• 1228386-55-7 C₃₃H₂₅N₅O₆S 
• 1228386-56-8 C₃₄H₂₈N₆O₅S 
• 1228386-57-9 C₃₂H₂₃N₅O₅S 
• 1262983-75-4 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide 
• 1262983-76-5 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxamide 
• 1262983-77-6 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxamide 
• 1262983-78-7 1-(2-(phthalimido-N-oxy)ethyl)-2,6-dimethyl-N₃,N₅-bis(4-oxo-2-phenylquinazolin-3(4H)-yl)-4-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxamide 

Relevant academic research and scientific papers

Preparation of 2-aminooxyethyliminodiacetic acid, a bifunctional chelating agent for carbonyl labeling

2-Aminooxyethyliminodiacetic acid, designed as a possible bifunctional chelating agent with a hydroxylamino group that can bind a carbonyl group of biomolecules, was synthesized by three different methods. Its oxime derivatives with some carbonyl compounds were readily prepared.

Extending the applicability of native chemical ligation

A more general approach to native (amide-forming) chemical ligation of unprotected peptide segments is described that extends the technique beyond the previously reported X-Cys ligation site to now include X-Gly and Gly-X ligation sites. A peptide, [pepti

Synthesis and Anti-inflammatory Screening of Some Mono and Bis-Alkoxyphthalimide Linked Benzimidazole and their Quinazoline and Pyrimidine Derivatives

In the present study, synthesis of some nonsymmetrical 2-(1H-benzimidazol-2-ylamino)-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one (3) and substituted-(1H-benzo[d]imidazol-2-yl)amino-pyrimidine derivatives (4a, 4b, 4c and 5a, 5b) is described as a three-component reaction of 2-guanidinobenzimidazole (2) with triethyl orthoformate and different reactive methylene compounds. Subsequent condensation of compounds 3, 4a, 4b, 4c, and 5a, 5b with bromoethoxyphthalimide (1) gave final compounds 6, 7a, 7b, 7c, and 8a, 8b. Synthesized final compounds have been screened for their in-vivo anti-inflammatory activity against carrageenan-induced paw edema in albino rats. Diclofenac was used as standard anti-inflammatory agents. Some of the compounds exhibited significant anti-inflammatory activity, as compared to standard drug. Structures of synthesized compounds have been confirmed on the basis of chemical tests and spectral studies.

Synthesis, Radiosynthesis, and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [18F]FDR

We report the synthesis of five radiotracers incorporating different oxyamine spacers between the hypoxia-reactive 2-nitroimidazole moiety and the 5-[18F]-fluorodeoxyribose ([18F]FDR, 12) prosthetic group: three linear alkyl chains w

Merging C-H Activation and Strain-Release in Ruthenium-Catalyzed Isoindolinone Synthesis

The merger of strain-release of 1,2-oxazetidines with carboxylic acid directed C-H activation in catalytic synthesis of isoindolinones is reported for the first time. This reaction opens a new and sustainable avenue to prepare a range of structurally dive

Merging alkenyl C-H activation with the ring-opening of 1,2-oxazetidines: Ruthenium-catalyzed aminomethylation of enamides

1,2-Oxazetidines have been utilized as formaldimine precursors for the direct aminomethylation of enamides under a Ru(ii) species. By merging alkenyl C-H activation with ring-opening of 1,2-oxazetidines, this efficient protocol provides a facile and novel

Cobalt-Catalyzed N-O and C-C Bond Cleavage in 1,2-Oxazetidines: Solvent-Controlled C-H Aminomethylation and Hydroxymethylation of Heteroarenes

An efficient cobalt-catalyzed ring-opening reaction of bench-stable 1,2-oxazetidines with heteroarenes was unprecedentedly developed. The sustainable Cp?Co(III) catalyst enables a distinctive merger of C-H activation with concomitant N-O and C-C cleavages of 1,2-oxazetidine, leading to site-selective C-H aminomethylation and hydroxymethylation of heteroaromatic compounds containing a broad range of functional groups. Preliminary control experiments unravel some essential mechanistic features of this one-pot transformation.

1,2-oxygen azetidines compound and preparation method and application thereof

The invention discloses a 1,2-oxygen azetidines compound and preparation method and application thereof. The N-hydroxyphthalimide is reacted with 1,2-dibromoethane and triethylamine to obtain compoundIII; the compound III is reacted with hydrobromic acid

Prosthetic group linking arm, method for synthesizing same and method for synthesizing di-ubiquitin

The invention provides a process for synthesizing a prosthetic group linking arm and a method for synthesizing di-ubiquitin by the aid of the prosthetic group linking arm. The prosthetic group linkingarm, the process and the method have the advantages that the prosthetic group linking arm is easy to synthesize and store and stable in chemical property; the prosthetic group linking arm is high inchemical linking efficiency in procedures for synthesizing the di-ubiquitin by the aid of the novel prosthetic group linking arm, and protein linking can be carried out under physiological conditions;the novel prosthetic group linking arm can be removed under mild conditions, and accordingly harsh non-denaturation conditions in prosthetic group removal procedures for chemical synthetic protein ubiquitination at present can be omitted.

INDOLINONES COMPOUNDS AND THEIR USE IN THE TREATMENT OF FIBROTIC DISEASES

The present invention relates inter alia to a compound of formula (I) Wherein R1, R2, R3 and Z are as defined in the specification and to compositions comprising the same and to the use of the compounds and to compositions of the compounds in treatment, for example in the treatment of fibrotic diseases or interstitial lung diseases, in particular idiopathic pulmonary fibrosis.