5-(3-(tert-butyl)phenyl)-1,3,4-oxadiazol-2-amine

Base Information

Chemical Name:5-(3-(tert-butyl)phenyl)-1,3,4-oxadiazol-2-amine
CAS No.:1450828-18-8
Molecular Formula:C₁₂H₁₅N₃O
Molecular Weight:217.271
Hs Code.:

Synonyms:

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Chemical Property of 5-(3-(tert-butyl)phenyl)-1,3,4-oxadiazol-2-amine

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Technology Process of 5-(3-(tert-butyl)phenyl)-1,3,4-oxadiazol-2-amine

There total 3 articles about 5-(3-(tert-butyl)phenyl)-1,3,4-oxadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1450828-16-6
(3-(tert-butyl)benzoyl)thiosemicarbazide

: 1450828-18-8
5-(3-(tert-butyl)phenyl)-1,3,4-oxadiazol-2-amine

Guidance literature:: With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium iodide; sodium hydroxide; In water; isopropyl alcohol; acetonitrile; at 0 - 4 ℃; for 1h;
DOI:10.1021/jm400830r

Reference yield:

: 7498-54-6
3-t-Butylbenzoic acid

: 1450828-18-8
5-(3-(tert-butyl)phenyl)-1,3,4-oxadiazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux; Inert atmosphere

2: tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

3: potassium iodide; sodium hydroxide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / isopropyl alcohol; water; acetonitrile / 1 h / 0 - 4 °C

With oxalyl dichloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; N,N-dimethyl-formamide; potassium iodide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm400830r

Reference yield:

: 21900-36-7
3-(tert-butyl)benzoyl chloride

: 1450828-18-8
5-(3-(tert-butyl)phenyl)-1,3,4-oxadiazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

2: potassium iodide; sodium hydroxide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / isopropyl alcohol; water; acetonitrile / 1 h / 0 - 4 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium iodide; sodium hydroxide; In tetrahydrofuran; water; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm400830r