7498-54-6

Usage

Uses

Used in Fragrance Industry:
3-(tert-Butyl)benzoic acid is used as a fragrance ingredient for its distinct odor characteristic, contributing to the creation of various scents in perfumes and other fragranced products.
Used in Cosmetics:
In the cosmetics industry, 3-(tert-Butyl)benzoic acid is used as a functional ingredient, potentially for its preservative properties or to enhance the stability and performance of cosmetic formulations.
Used in Food Additives:
3-(tert-Butyl)benzoic acid is used as a food additive, likely for its ability to extend the shelf life of products or to provide a specific flavor or aroma.
Used in Pharmaceuticals:
In the pharmaceutical industry, 3-(tert-Butyl)benzoic acid may be used as an active pharmaceutical ingredient or as a component in drug formulations, potentially due to its chemical properties that could contribute to the efficacy or stability of medications.
Used in Plastics Industry:
3-(tert-Butyl)benzoic acid is used in the plastics industry, possibly as a plasticizer, stabilizer, or to enhance the properties of plastic materials, such as durability or resistance to degradation.

InChI:InChI=1/C11H14O2/c1-11(2,3)9-6-4-5-8(7-9)10(12)13/h4-7H,1-3H3,(H,12,13)

Upstream product

• 253185-03-4 tert-butylbenzene 
• 1075-38-3 m-t-butyltoluene 
• 20033-12-9 1-tert-butyl-3-isopropylbenzene 
• 3972-55-2 1-tert-butyl-3-chloro-benzene 
• 154532-34-0 3-tert-butyl-1-cyanobenzene 
• 102405-32-3 3-tert-butylbenzyl bromide 
• 25469-14-1 4-tert-butyl-tropolone 
• 40782-26-1 3-tert-butyl-benzoic acid amide 
• 124-38-9 carbon dioxide 
• 27330-57-0 methyl 3-(tert-butyl)benzoate 
• 15719-64-9 methylammonium carbonate 
• 7697-37-2 nitric acid 
• 23039-28-3 3-(tert-butyl)benzaldehyde 
• 64-18-6 formic acid 

Downstream Products

• 6136-71-6 1-(3-(tert-butyl)phenyl)ethan-1-one 
• 104729-88-6 (E)-1-(4-(tert-butyl)phenyl)-1,2-diphenylethylene 
• 84603-40-7 3-tert.-Butyl-4'-methyl-benzophenon 
• 21900-36-7 3-(tert-butyl)benzoyl chloride 
• 60772-72-7 2-chloro-5-t-butylbenzoic acid 
• 2475-77-6 2-amino-5-(1,1-dimethylethyl)benzoic acid 

Relevant academic research and scientific papers

HETEROCYCLIC CYTOKINE INHIBITORS

The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory, anti-pain or anti-cancer agents. There are further provided m

COMPOUNDS USEFUL AS ANTAGONISTS OF CCR2

The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful

QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS

The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

QUINOXALINES AS B RAF INHIBITORS

The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

An efficient Pd(II)-based catalyst system for carboxylation of aromatic C-H bond by addition of a phosphenium salt

Addition of a phosphenium dramatically improved the reaction yields in the carboxylation of arenes by formic acid catalyzed by Pd(II). Control experiments revealed that the majority of the phosphenium triflate was converted to a mixed anhydride of phosphonic acid and formic acid (7), which however did not substitute for the phosphenium to improve the reaction yield.

SUBSTITUTED QUINAZOLONES AS ANTI-CANCER AGENTS

The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

Palladium(II)-catalyzed sequential hydroxylation-carboxylation of biphenyl using formic acid as a carbonyl source

(Equation Presented) A simultaneous hydroxylation-carboxylation of biphenyl occurred to give 4′-hydroxy-4-biphenylcarboxylic acid, which has wide potential application as a polyester monomer.

OPIOID RECEPTOR ACTIVE COMPOUNDS

The invention provides compounds of formula I: wherein R1 to R4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating pain and treating other conditions which involve, for example, binding opioid receptors using compounds of formula I.

FURTHER STUDIES ON THE EXTENDED HAMMETT EQUATION COMPRISING THE HYDROPHOBIC CONSTANT: REACTIVITY DATA FOR BENZOIC ACIDS, ARYLACETIC ACIDS, β-ARYLPROPIONIC ACIDS, trans- AND cis-CINNAMIC ACIDS, METHYL BENZOATES; DISSOCIATION CONSTANTS, DDM REACTION AND ALKALINE HYDROLYSIS IN VARIOUS W...

The extended Hammett equation Δ = ρ? + h? comprising the hydrophobic constant ? is found to be effective in the title compounds and reactivities in various solvent mixtures.In 32 vol.percent tert-butanol-water hm decreases in the order ArCOOMe (-0.25), cis-ArCH=CHCOOH (-0.18), ArCOOH and ArCH2COOH (-0.16), ArCH2CH2COOH and trans-ArCH=CHCOOH (-0.07).For ArCOOH, mixtures like 40-60percent methanol, 50percent ethanol, 50percent acetone and 50percent dioxane give similar hm values of circa -0.05.For ArCH2COOH the effects of 3-iodo and 4-iodo substituents are acid-weakening in32percent tert-butanol.The consequences of the h? term for ρ, ?, and the averaging of ? values, are discussed.

SELECTIVE MONO- OR DIMETALATION OF ARENES BY MEANS OF SUPERBASIC REAGENTS

If employed in tetrahydrofuran, stoichiometric amounts of butyllithium and potassium tert-butoxide react with benzene under clean monometalation.In hexane suspension, however, considerable amounts of meta- and para-disubstituted by-products are obtained (approx. 10percent).They become preponderant if a three-fold excess of the metalating agent is used.Naphthalene leads under the same conditions to a mixture of two mono- and ten di-substituted derivatives. - Alkyl groups, as present in tert-butylbenzene, retard the metalation at both m- and p-positions, while trialkylsilyl groups deactivate only m-position.In either case exclusive monosubstitution occurs. - Perdeuterobenzene undergoes metalation and subsequent electrophilic mono- or disubstitution to afford isotope labeled compounds with moderate, though synthetically attractive yields.The kinetic isotope effects and product ratios can be taken as evidence for aggregate formation at the level of both the superbasic metalating reagent and the organometallic intermediates.