Technology Process of 5-phenyl-[1,2,4]oxadiazole-3-carboxylic acid anilide
There total 8 articles about 5-phenyl-[1,2,4]oxadiazole-3-carboxylic acid anilide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2,2-dichloro-1,3-dicyclohexylimidazolidine-4,5-dione / acetonitrile / 0.5 h / 25 °C / Schlenk technique; Inert atmosphere
2: hydroxylamine hydrochloride; pyridine / toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique
3: toluene / 1.5 h / Inert atmosphere; Schlenk technique; Reflux
4: tetrabutyl ammonium fluoride / toluene; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
With
pyridine; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; 2,2-dichloro-1,3-dicyclohexylimidazolidine-4,5-dione;
In
tetrahydrofuran; toluene; acetonitrile;
DOI:10.1021/acs.joc.9b02992
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; pyridine / toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique
2: toluene / 1.5 h / Inert atmosphere; Schlenk technique; Reflux
3: tetrabutyl ammonium fluoride / toluene; tetrahydrofuran / Inert atmosphere; Schlenk technique; Reflux
With
pyridine; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; toluene;
DOI:10.1021/acs.joc.9b02992
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran; toluene;
Inert atmosphere;
Schlenk technique;
Reflux;
DOI:10.1021/acs.joc.9b02992
