{(1S,2S)-1-Benzyl-3-[(R)-5,5-dimethyl-4-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{(1S,2S)-1-Benzyl-3-[(R)-5,5-dimethyl-4-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propyl}-carbamic acid tert-butyl ester
CAS No.:359690-90-7
Molecular Formula:C₂₇H₄₂N₄O₆S
Molecular Weight:550.72
Hs Code.:

{(1S,2S)-1-Benzyl-3-[(R)-5,5-dimethyl-4-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propyl}-carbamic acid tert-butyl ester

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Chemical Property of {(1S,2S)-1-Benzyl-3-[(R)-5,5-dimethyl-4-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propyl}-carbamic acid tert-butyl ester

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Technology Process of {(1S,2S)-1-Benzyl-3-[(R)-5,5-dimethyl-4-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propyl}-carbamic acid tert-butyl ester

There total 7 articles about {(1S,2S)-1-Benzyl-3-[(R)-5,5-dimethyl-4-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6306-52-1
L-valine methylester hydrochloride

: 359690-90-7
{(1S,2S)-1-Benzyl-3-[(R)-5,5-dimethyl-4-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆; triethylamine / dimethylformamide

2: HCl / CH₂Cl₂; dioxane / 4 h

3: 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆; triethylamine / dimethylformamide

4: 100 percent / LiOH / methanol; tetrahydrofuran; H₂O / 4 h

5: 1-hydroxybenzotriazole hydrate; 1,3-dicyclohexylcarbodiimide / 1,2-dichloro-ethane / 24 h

6: tetrahydrofuran / 1 h

With hydrogenchloride; lithium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(00)00346-1

Reference yield:

: 117918-23-7
(R)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

: 359690-90-7
{(1S,2S)-1-Benzyl-3-[(R)-5,5-dimethyl-4-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆; triethylamine / dimethylformamide

2: HCl / CH₂Cl₂; dioxane / 4 h

3: 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆; triethylamine / dimethylformamide

4: 100 percent / LiOH / methanol; tetrahydrofuran; H₂O / 4 h

5: 1-hydroxybenzotriazole hydrate; 1,3-dicyclohexylcarbodiimide / 1,2-dichloro-ethane / 24 h

6: tetrahydrofuran / 1 h

With hydrogenchloride; lithium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(00)00346-1

Reference yield:

: (S)-2-[((R)-5,5-Dimethyl-thiazolidine-4-carbonyl)-amino]-3-methyl-butyric acid methyl ester

: 359690-90-7
{(1S,2S)-1-Benzyl-3-[(R)-5,5-dimethyl-4-((S)-2-methyl-1-methylcarbamoyl-propylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆; triethylamine / dimethylformamide

2: 100 percent / LiOH / methanol; tetrahydrofuran; H₂O / 4 h

3: 1-hydroxybenzotriazole hydrate; 1,3-dicyclohexylcarbodiimide / 1,2-dichloro-ethane / 24 h

4: tetrahydrofuran / 1 h

With lithium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(00)00346-1