Benzoic acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-methyl-phosphinoyloxy]-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Base Information

• Chemical Name: Benzoic acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-methyl-phosphinoyloxy]-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
• CAS No.: 116872-53-8
• Molecular Formula: C₃₀H₂₇N₆O₈P
• Molecular Weight: 630.554

Synonyms:

Chemical Property of Benzoic acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-methyl-phosphinoyloxy]-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Chemical Property:

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Technology Process of Benzoic acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-methyl-phosphinoyloxy]-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

There total 2 articles about Benzoic acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-methyl-phosphinoyloxy]-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzotriazol-1-ol (2592-95-2) → Benzoic acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-methyl-phosphinoyloxy]-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (116872-53-8,116872-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 8 h / Ambient temperature

2: dioxane / 1 h / Ambient temperature

With pyridine; In 1,4-dioxane;

DOI:10.1016/S0040-4039(00)80262-2

Reference yield:

O,O-bis(benzotriazol-1-yl)methylphosphonate (103215-29-8) + (5'-O,4-N)-dibenzoyl-2'-deoxycytidine (4803-92-3) → Benzoic acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-methyl-phosphinoyloxy]-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (116872-53-8,116872-70-9)

Guidance literature:

In 1,4-dioxane; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(00)80262-2

Reference yield:

Benzoic acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-methyl-phosphinoyloxy]-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (116872-53-8,116872-70-9) + phenylmethanethiol (100-53-8) → 5'-O-N4-dibenzoyldeoxycytidine 3'-O(S-benzyl)methylphosphonothioate (116872-63-0,116872-79-8)

Guidance literature:

With 1-methyl-1H-imidazole; for 5h; Yield given; Ambient temperature;

DOI:10.1016/S0040-4039(00)80262-2

upstream raw materials:

O,O-bis(benzotriazol-1-yl)methylphosphonate

(5'-O,4-N)-dibenzoyl-2'-deoxycytidine

benzotriazol-1-ol

Downstream raw materials:

5'-O-N⁴-dibenzoyldeoxycytidine 3'-O(S-benzyl)methylphosphonothioate

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