Benzenesulfonamide, 4-(5-amino-3-methyl-1H-pyrazol-1-yl)-

Base Information

• Chemical Name: Benzenesulfonamide, 4-(5-amino-3-methyl-1H-pyrazol-1-yl)-
• CAS No.: 103038-27-3
• Molecular Formula: C10H12N4O2S
• Molecular Weight: 252.29300
• Mol file: 103038-27-3.mol

Synonyms:4-(5-amino-3-methyl-pyrazol-1-yl)-benzenesulfonamide;5-Amino-3-methyl-1-<4-aminosulfo-phenyl>pyrazol;4-(5-Amino-3-methyl-pyrazol-1-yl)-benzolsulfonsaeure-amid;4-(5-amino-3-methyl-pyrazol-1-yl)-benzenesulfonic acid amide;

Chemical Property of Benzenesulfonamide, 4-(5-amino-3-methyl-1H-pyrazol-1-yl)-

Chemical Property:

• Melting Point: 227 - 228 °C
• PSA: 112.38000
• LogP: 2.77260

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenesulfonamide, 4-(5-amino-3-methyl-1H-pyrazol-1-yl)-

There total 4 articles about Benzenesulfonamide, 4-(5-amino-3-methyl-1H-pyrazol-1-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

→ 4-(5-amino-3-methyl-1H-pyrazol-1-yl)benzenesulfonamide (103038-27-3)

Guidance literature:

Reference yield: 77.0%

3-Aminocrotononitrile (1118-61-2) + 4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0) → 4-(5-amino-3-methyl-1H-pyrazol-1-yl)benzenesulfonamide (103038-27-3)

Guidance literature:

With hydrogenchloride; In water; Reflux;

DOI:10.1002/jhet.3150

Reference yield:

4-aminosulfonylphenylhydrazine (4392-54-5) + 3-iminobutyronitrile (1118-60-1) → 4-(5-amino-3-methyl-1H-pyrazol-1-yl)benzenesulfonamide (103038-27-3)

Guidance literature:

4-aminosulfonylphenylhydrazine; With hydrogenchloride; In water; at 50 ℃; for 0.166667h;

3-iminobutyronitrile; In ethanol; water; at 50 ℃; for 0.166667h;

With hydrogenchloride; In ethanol; water; for 0.25h; Reflux;

DOI:10.1016/j.bioorg.2020.103989

upstream raw materials:

buta-2,3-dienenitrile

4-aminosulfonylphenylhydrazine

3-Aminocrotononitrile

4-hydrazinobenzene-1-sulfonamide hydrochloride