4-chloro-3-cyanomethylpyridine

Base Information

• Chemical Name: 4-chloro-3-cyanomethylpyridine
• CAS No.: 142892-30-6
• Molecular Formula: C₇H₅ClN₂
• Molecular Weight: 152.583
• Mol file: 142892-30-6.mol

Synonyms:

Chemical Property of 4-chloro-3-cyanomethylpyridine

Chemical Property:

• Boiling Point: 281.0±25.0 °C(Predicted)
• Density: 1.262±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

4-Chloropyridine-3-acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-3-cyanomethylpyridine

There total 1 articles about 4-chloro-3-cyanomethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

3-(cyanomethyl)pyridine 1-oxide (6635-88-7) → (6-chloro-pyridin-3-yl)-acetonitrile (39891-09-3) + 2-(2-chloropyridin-3-yl)acetonitrile (101012-32-2) + 4-chloro-3-cyanomethylpyridine (142892-30-6)

Guidance literature:

With trichlorophosphate; for 3h; Heating;

DOI:10.1055/s-1992-26153

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + 4-chloro-3-cyanomethylpyridine (142892-30-6) + methyl iodide (74-88-4) → 2-Methylsulfanyl-thieno[3,2-c]pyridine-3-carbonitrile (142892-33-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1a) DMSO, RT, 1b) 70 deg C, 2) RT;

DOI:10.1055/s-1992-26153

Reference yield:

phenyl isothiocyanate (103-72-0) + 4-chloro-3-cyanomethylpyridine (142892-30-6) → 2-Phenylamino-thieno[3,2-c]pyridine-3-carbonitrile

Guidance literature:

With sodium hydride; methyl iodide; Yield given. Multistep reaction; 1.) DMSO, r.t., 1 h; 70 deg C, 1 h, 2.) r.t., 1 h;

DOI:10.1055/s-1998-2124

upstream raw materials:

3-(cyanomethyl)pyridine 1-oxide

Downstream raw materials:

2-Methylsulfanyl-thieno[3,2-c]pyridine-3-carbonitrile