1-Benzyl-2-cyano-6-propyl-3-piperideine

Base Information

• Chemical Name: 1-Benzyl-2-cyano-6-propyl-3-piperideine
• CAS No.: 86963-77-1
• Molecular Formula: C₁₆H₂₀N₂
• Molecular Weight: 240.348
• Mol file: 86963-77-1.mol

Synonyms:

Chemical Property of 1-Benzyl-2-cyano-6-propyl-3-piperideine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-2-cyano-6-propyl-3-piperideine

There total 4 articles about 1-Benzyl-2-cyano-6-propyl-3-piperideine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) → 1-Benzyl-2-cyano-6-propyl-3-piperideine (86963-77-1,86963-78-2,89873-60-9,89873-61-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent

2: NaBH₄ / ethanol / Ambient temperature

3: m-chloroperbenzoic acid / CH₂Cl₂ / 40 °C

4: 1) (CF₃CO)2O / 1) CH₂Cl₂, 1 h, r.t. 2) 30 min, r.t., pH 4.0 (NaOAc or AcOH)

With sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In ethanol; dichloromethane;

DOI:10.1021/jo00187a018

Reference yield:

1-benzyl-2-propyl-1,2,3,6-tetrahydropyridine → 1-Benzyl-2-cyano-6-propyl-3-piperideine (86963-77-1,86963-78-2,89873-60-9,89873-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: m-chloroperbenzoic acid / CH₂Cl₂ / 40 °C

2: 1) (CF₃CO)2O / 1) CH₂Cl₂, 1 h, r.t. 2) 30 min, r.t., pH 4.0 (NaOAc or AcOH)

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane;

DOI:10.1021/jo00187a018

Reference yield:

1-benzyl-2-propylpyridinium bromide → 1-Benzyl-2-cyano-6-propyl-3-piperideine (86963-77-1,86963-78-2,89873-60-9,89873-61-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / ethanol / Ambient temperature

2: m-chloroperbenzoic acid / CH₂Cl₂ / 40 °C

3: 1) (CF₃CO)2O / 1) CH₂Cl₂, 1 h, r.t. 2) 30 min, r.t., pH 4.0 (NaOAc or AcOH)

With sodium tetrahydroborate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In ethanol; dichloromethane;

DOI:10.1021/jo00187a018

upstream raw materials:

potassium cyanide

1-Benzyl-2-propyl-3,6-dihydro-2H-pyridine 1-oxide

benzyl bromide

Downstream raw materials:

(2R,6R)-1-Benzyl-2-[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-6-propyl-piperidine-2-carbonitrile

(2S,6R)-1-Benzyl-6-propyl-piperidine-2-carbonitrile

1-Benzyl-2-cyano-6-propyl-4-piperideine