7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1-<(ethoxycarbonyl)acetyl>-1H-1,4-benzodiazepine-2-acetic acid methyl ester

Base Information

• Chemical Name: 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1-<(ethoxycarbonyl)acetyl>-1H-1,4-benzodiazepine-2-acetic acid methyl ester
• CAS No.: 112634-63-6
• Molecular Formula: C₂₃H₂₂ClFN₂O₅
• Molecular Weight: 460.889
• Mol file: 112634-63-6.mol

Synonyms:

Chemical Property of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1-<(ethoxycarbonyl)acetyl>-1H-1,4-benzodiazepine-2-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1-<(ethoxycarbonyl)acetyl>-1H-1,4-benzodiazepine-2-acetic acid methyl ester

There total 2 articles about 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1-<(ethoxycarbonyl)acetyl>-1H-1,4-benzodiazepine-2-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetic acid methyl ester (112634-51-2) + ethyl chlorocarbonylacetate (36239-09-5) → 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1-<(ethoxycarbonyl)acetyl>-1H-1,4-benzodiazepine-2-acetic acid methyl ester (112634-63-6)

Guidance literature:

In benzene; for 0.5h; Heating;

DOI:10.1002/jhet.5570240327

Reference yield:

7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester (59468-40-5) → 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1-<(ethoxycarbonyl)acetyl>-1H-1,4-benzodiazepine-2-acetic acid methyl ester (112634-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / triethylsilane / trifluoroacetic acid / 0.5 h

2: 88 percent / benzene / 0.5 h / Heating

With triethylsilane; In trifluoroacetic acid; benzene;

DOI:10.1002/jhet.5570240327

Reference yield:

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1-<(ethoxycarbonyl)acetyl>-1H-1,4-benzodiazepine-2-acetic acid methyl ester (112634-63-6) → 9-chloro-7-(2-fluorophenyl)-1,5-dihydro-3-hydroxy-1-oxopyrido<1,2-a><1,4>benzodiazepine-2-carboxylic acid methyl ester (112634-69-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1. sodium methoxide / 1. methanol, reflux, 5 min.; 2. dichloromethane, 30 min.

2: 64 percent / act. MnO₂ / toluene / 0.33 h / Heating

3: 17 percent / KOH / methanol; H₂O / 4 h / Heating

With manganese(IV) oxide; potassium hydroxide; sodium methylate; In methanol; water; toluene;

DOI:10.1002/jhet.5570240327

upstream raw materials:

7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2-acetic acid methyl ester

ethyl chlorocarbonylacetate

7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-ylidene acetic acid methyl ester

Downstream raw materials:

9-chloro-7-(2-fluorophenyl)-1,4,4a,5-tetrahydro-3-methoxy-1-oxopyrido<1,2-a><1,4>benzodiazepine-2-carboxylic acid methyl ester

9-chloro-7-(2-fluorophenyl)-1,5-dihydro-3-hydroxy-1-oxopyrido<1,2-a><1,4>benzodiazepine-2-carboxylic acid methyl ester

9-chloro-7-(2-fluorophenyl)-1,5-dihydro-3-methylamino-1-oxopyrido<1,2-a><1,4>benzodiazepine-2-carboxylic acid methyl ester

9-chloro-7-(2-fluorophenyl)-1,5-dihydro-3-methoxy-1-oxopyrido<1,2-a><1,4>benzodiazepine-2-carboxylic acid methyl ester