C₂₅H₃₁N₆O₈P

Base Information

• Chemical Name: C₂₅H₃₁N₆O₈P
• CAS No.: 1384122-46-6
• Molecular Formula: C₂₅H₃₁N₆O₈P
• Molecular Weight: 574.53
• Mol file: 1384122-46-6.mol

Synonyms:

Chemical Property of C₂₅H₃₁N₆O₈P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₃₁N₆O₈P

There total 8 articles about C₂₅H₃₁N₆O₈P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-[(R)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester (1256490-49-9) + 1′-cyano-2′-C-methyl-4-aza-7,9-dideazaadenosine (1191237-49-6) → C25H31N6O8P (1384122-46-6)

Guidance literature:

1′-cyano-2′-C-methyl-4-aza-7,9-dideazaadenosine; With tert-butylmagnesium chloride; In tetrahydrofuran; water; at 20 ℃; for 0.333333h;

(S)-2-[(R)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester; In tetrahydrofuran; water; at 50 ℃; for 2.5h;

DOI:10.1021/jm400201a

Reference yield:

(S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester (1256490-48-8) → C25H31N6O8P (1384122-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Chiralpak IC / n-heptane; isopropyl alcohol / Resolution of racemate

2.1: tert-butylmagnesium chloride / tetrahydrofuran; water / 0.33 h / 20 °C

2.2: 2.5 h / 50 °C

With tert-butylmagnesium chloride; In tetrahydrofuran; n-heptane; water; isopropyl alcohol;

DOI:10.1021/jm400201a

Reference yield:

2′,3′,5′-O-tribenzyl-1′-hydroxy-2′-C-methyl-4-aza-7,9-dideazaadenosine → C25H31N6O8P (1384122-46-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trimethylsilyl trifluoromethanesulfonate / toluene; dichloromethane / 2 h / -15 - 0 °C

2.1: boron trichloride / dichloromethane / 1.16 h / 0 °C

2.2: 1 h / 0 - 20 °C

3.1: tert-butylmagnesium chloride / tetrahydrofuran; water / 0.33 h / 20 °C

3.2: 2.5 h / 50 °C

With trimethylsilyl trifluoromethanesulfonate; tert-butylmagnesium chloride; boron trichloride; In tetrahydrofuran; dichloromethane; water; toluene;

DOI:10.1021/jm400201a

upstream raw materials:

(S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

(S)-2-[(R)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

1′-cyano-2′-C-methyl-4-aza-7,9-dideazaadenosine

7-bromo-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine

Downstream raw materials:

C₂₉H₃₇N₆O₉P