(3R)-5-(2-fluorophenyl)-1-methyl-3-[(1-methylindol-3-yl)methyl]-3H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:(3R)-5-(2-fluorophenyl)-1-methyl-3-[(1-methylindol-3-yl)methyl]-3H-1,4-benzodiazepin-2-one
CAS No.:103342-81-0
Molecular Formula:C₂₆H₂₂FN₃O
Molecular Weight:411.479
Hs Code.:
ChEMBL ID:CHEMBL1907729
DSSTox Substance ID:DTXSID601109013
Mol file:103342-81-0.mol

Synonyms:CHEMBL1907729;DTXSID601109013;BDBM50367523;103342-81-0;2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-1-methyl-3-[(1-methyl-1H-indol-3-yl)methyl]-, (R)-

Suppliers and Price of (3R)-5-(2-fluorophenyl)-1-methyl-3-[(1-methylindol-3-yl)methyl]-3H-1,4-benzodiazepin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R)-5-(2-fluorophenyl)-1-methyl-3-[(1-methylindol-3-yl)methyl]-3H-1,4-benzodiazepin-2-one

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:411.17469050
Heavy Atom Count:31
Complexity:696

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=C(C2=CC=CC=C21)CC3C(=O)N(C4=CC=CC=C4C(=N3)C5=CC=CC=C5F)C
Isomeric SMILES:CN1C=C(C2=CC=CC=C21)C[C@@H]3C(=O)N(C4=CC=CC=C4C(=N3)C5=CC=CC=C5F)C

Technology Process of (3R)-5-(2-fluorophenyl)-1-methyl-3-[(1-methylindol-3-yl)methyl]-3H-1,4-benzodiazepin-2-one

There total 2 articles about (3R)-5-(2-fluorophenyl)-1-methyl-3-[(1-methylindol-3-yl)methyl]-3H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103342-82-1
L-364373

: 74-88-4
methyl iodide

: 103342-81-0
(R)-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-3-((1-methyl-1H-indol-3-yl)methyl)-2H-1,4-benzodiazepin-2-one

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 40 min, 2.) DMF, from 0 deg C to RT, 20 min;
DOI:10.1021/jm00390a019

Reference yield:

: 102671-70-5
(R)-5-(2-fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-2H-1,4-benzodiazepin-2-one

: 74-88-4
methyl iodide

: 103342-82-1
L-364373

: 103342-81-0
(R)-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-3-((1-methyl-1H-indol-3-yl)methyl)-2H-1,4-benzodiazepin-2-one

Guidance literature:: With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, 0 deg C, 40 min, 2.) DMF, from 0 deg C to RT, 20 min;
DOI:10.1021/jm00390a019