CCK antagonist synthetic 8

Base Information

Chemical Name:CCK antagonist synthetic 8
CAS No.:103342-83-2
Molecular Formula:C₂₄H₁₉N₃O
Molecular Weight:365.434
Hs Code.:
ChEMBL ID:CHEMBL1907740
DSSTox Substance ID:DTXSID901140814
Mol file:103342-83-2.mol

Synonyms:CCK antagonist synthetic 8;SCHEMBL9526199;CHEMBL1907740;BDBM82391;FAERGZYQYDZYEL-JOCHJYFZSA-N;DTXSID901140814;103342-83-2;(3R)-1,3-Dihydro-3-(1H-indol-3-ylmethyl)-5-phenyl-2H-1,4-benzodiazepin-2-one;3(R)-[(1H-indol-3-yl)methyl]-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Suppliers and Price of CCK antagonist synthetic 8

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of CCK antagonist synthetic 8

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:365.152812238
Heavy Atom Count:28
Complexity:597

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NC(C(=O)NC3=CC=CC=C32)CC4=CNC5=CC=CC=C54
Isomeric SMILES:C1=CC=C(C=C1)C2=N[C@@H](C(=O)NC3=CC=CC=C32)CC4=CNC5=CC=CC=C54

Technology Process of CCK antagonist synthetic 8

There total 4 articles about CCK antagonist synthetic 8 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108869-19-8
(R)-2-Amino-N-(2-benzoyl-phenyl)-3-(1H-indol-3-yl)-propionamide; hydrochloride

: 103342-83-2
(R)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-5-phenyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: With sodium hydroxide; In methanol; for 72h; Yield given; Ambient temperature;
DOI:10.1021/jm00390a019

Reference yield:

: 5241-64-5
Boc-D-Trp-OH

: 103342-83-2
(R)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-5-phenyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CH₂Cl₂ / Ambient temperature

2: HCl(g) / ethyl acetate / 0.33 h

3: aq. NaOH / methanol / 72 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00390a019

Reference yield:

: 103143-99-3
[(R)-1-(2-Benzoyl-phenylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

: 103342-83-2
(R)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-5-phenyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: HCl(g) / ethyl acetate / 0.33 h

2: aq. NaOH / methanol / 72 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; In methanol; ethyl acetate;
DOI:10.1021/jm00390a019