2H-1,4-Benzodiazepin-2-one, 1-[2-(dimethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-3-(1H-indol-3- ylmethyl)-, (R)-

Base Information

Chemical Name:2H-1,4-Benzodiazepin-2-one, 1-[2-(dimethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-3-(1H-indol-3- ylmethyl)-, (R)-
CAS No.:103343-10-8
Molecular Formula:C₂₈H₂₇FN₄O
Molecular Weight:454.547
Hs Code.:
Mol file:103343-10-8.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-1,4-Benzodiazepin-2-one, 1-[2-(dimethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-3-(1H-indol-3- ylmethyl)-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-1,4-Benzodiazepin-2-one, 1-[2-(dimethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-3-(1H-indol-3- ylmethyl)-, (R)-

There total 5 articles about 2H-1,4-Benzodiazepin-2-one, 1-[2-(dimethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-3-(1H-indol-3- ylmethyl)-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1581-13-1
2-amino-2'-fluorobenzophenone

: 103343-10-8
1,3-Dihydro-1-(2-dimethylaminoethyl)-5-(2-fluorophenyl) 3(R)-(3'-indolyl)methyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / 0 °C

2: aq. NaOH / methanol / 72 h

3: 1.) NaH / 1.) DMF, 0 deg C, 40 min, 2.) DMF, from 0 deg C to RT, 20 min

With sodium hydroxide; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1021/jm00390a019

Reference yield:

: 103222-66-8
D-tryptophan acid chloride hydrochloride

: 103343-10-8
1,3-Dihydro-1-(2-dimethylaminoethyl)-5-(2-fluorophenyl) 3(R)-(3'-indolyl)methyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / 0 °C

2: aq. NaOH / methanol / 72 h

3: 1.) NaH / 1.) DMF, 0 deg C, 40 min, 2.) DMF, from 0 deg C to RT, 20 min

With sodium hydroxide; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1021/jm00390a019

Reference yield:

: 103342-80-9
2-N-(D-tryptophanyl)amino-2'-fluorobenzophenonehydrochloride

: 103343-10-8
1,3-Dihydro-1-(2-dimethylaminoethyl)-5-(2-fluorophenyl) 3(R)-(3'-indolyl)methyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / methanol / 72 h

2: 1.) NaH / 1.) DMF, 0 deg C, 40 min, 2.) DMF, from 0 deg C to RT, 20 min

With sodium hydroxide; sodium hydride; In methanol;
DOI:10.1021/jm00390a019