2,7,12,17,22,27-Hexaazahentriacontanedioic acid, 28-[(1,1-dimethylethoxy)carbonyl]-6,11,16,21,26-pentaoxo-, 31-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (S)-

Base Information

Chemical Name:2,7,12,17,22,27-Hexaazahentriacontanedioic acid, 28-[(1,1-dimethylethoxy)carbonyl]-6,11,16,21,26-pentaoxo-, 31-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (S)-
CAS No.:103346-44-7
Molecular Formula:C41H66N6O11
Molecular Weight:819.009
Hs Code.:
Mol file:103346-44-7.mol

2,7,12,17,22,27-Hexaazahentriacontanedioic acid,
28-[(1,1-dimethylethoxy)carbonyl]-6,11,16,21,26-pentaoxo-,
31-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (S)-

Synonyms:

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Chemical Property of 2,7,12,17,22,27-Hexaazahentriacontanedioic acid, 28-[(1,1-dimethylethoxy)carbonyl]-6,11,16,21,26-pentaoxo-, 31-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,7,12,17,22,27-Hexaazahentriacontanedioic acid, 28-[(1,1-dimethylethoxy)carbonyl]-6,11,16,21,26-pentaoxo-, 31-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (S)-

There total 9 articles about 2,7,12,17,22,27-Hexaazahentriacontanedioic acid, 28-[(1,1-dimethylethoxy)carbonyl]-6,11,16,21,26-pentaoxo-, 31-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 103321-39-7
(S)-2-(4-Amino-butyrylamino)-pentanedioic acid di-tert-butyl ester; hydrochloride

: 103321-33-1
4-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-butyric acid

: 103346-44-7
(S)-2-[4-(4-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-butyrylamino]-pentanedioic acid di-tert-butyl ester

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm00160a014

Reference yield:

: 5105-78-2
4-(benzyloxycarbonylamino)butyric acid

: 103346-44-7
(S)-2-[4-(4-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-butyrylamino]-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / dimethylformamide / 0.33 h

2: Et₃N / dimethylformamide / 0.5 h

3: 97 percent / Ba(OH)2.8H₂O / ethanol; H₂O / Ambient temperature

4: Et₃N / dimethylformamide / 0.33 h

5: Et₃N / dimethylformamide / 0.5 h

6: 97 percent / Ba(OH)2.8H₂O / ethanol; H₂O / Ambient temperature

7: 47 percent / diphenylphosphoryl azide (DPPA), Et₃N / dimethylformamide / Ambient temperature

With barium dihydroxide; diphenylphosphoranyl azide; triethylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00160a014

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 103346-44-7
(S)-2-[4-(4-{4-[4-(4-Benzyloxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-butyrylamino]-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diphenylphosphoryl azide, Et₃N / dimethylformamide / Ambient temperature

2: 100 percent / HCl (gas), H₂ / 5percent Pd/C / methanol / 1 h

3: 47 percent / diphenylphosphoryl azide (DPPA), Et₃N / dimethylformamide / Ambient temperature

With hydrogenchloride; diphenylphosphoranyl azide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00160a014