Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyryl-α-glutamyl(γ-tert-butyl ester)-valinol

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Chemical Name:Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyryl-α-glutamyl(γ-tert-butyl ester)-valinol
CAS No.:83537-98-8
Molecular Formula:C₄₁H₆₆N₆O₁₀
Molecular Weight:803.009
Hs Code.:

Synonyms:

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Chemical Property of Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyryl-α-glutamyl(γ-tert-butyl ester)-valinol

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Technology Process of Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyryl-α-glutamyl(γ-tert-butyl ester)-valinol

There total 7 articles about Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyryl-α-glutamyl(γ-tert-butyl ester)-valinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 83537-98-8
Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyryl-α-glutamyl(γ-tert-butyl ester)-valinol

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / CH₂Cl₂ / 16 h / Ambient temperature

2: 77 percent / H₂ / Pd(10percent on charcoal) / methanol / 2 h

3: 1) N-methylmorpholine, isobutyl chloroformate, / 1) THF, 10 min, -15 deg C; 5h, 0 deg C, 2) 10h, room temp.

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; 10% palladium on active carbon; In methanol; dichloromethane;
DOI:10.1002/jlac.198219820909

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 83537-98-8
Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyryl-α-glutamyl(γ-tert-butyl ester)-valinol

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄, BF₃ / diethyl ether

2: 97 percent / CH₂Cl₂ / 16 h / Ambient temperature

3: 77 percent / H₂ / Pd(10percent on charcoal) / methanol / 2 h

4: 1) N-methylmorpholine, isobutyl chloroformate, / 1) THF, 10 min, -15 deg C; 5h, 0 deg C, 2) 10h, room temp.

With 4-methyl-morpholine; sodium tetrahydroborate; boron trifluoride; hydrogen; isobutyl chloroformate; 10% palladium on active carbon; In methanol; diethyl ether; dichloromethane;
DOI:10.1002/jlac.198219820909

Reference yield:

: 83537-83-1
Benzyloxycarbonyl-α-L-glutamyl(γ-tert-butyl ester)-valinol

: 83537-98-8
Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyryl-α-glutamyl(γ-tert-butyl ester)-valinol

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / H₂ / Pd(10percent on charcoal) / methanol / 2 h

2: 1) N-methylmorpholine, isobutyl chloroformate, / 1) THF, 10 min, -15 deg C; 5h, 0 deg C, 2) 10h, room temp.

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; 10% palladium on active carbon; In methanol;
DOI:10.1002/jlac.198219820909