Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid

Base Information

Chemical Name:Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid
CAS No.:83537-97-7
Molecular Formula:C₂₇H₄₀N₄O₇
Molecular Weight:532.637
Hs Code.:

Synonyms:Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid

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Chemical Property of Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid

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Technology Process of Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid

There total 3 articles about Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 83537-96-6
Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

: 83537-97-7
Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1002/jlac.198219820909

Reference yield:

: 83537-94-4
Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

: 83537-97-7
Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂ / Pd(10percent on charcoal) / methanol / 5 h

2: 1) N-methylmorpholine, isobutyl chloroformate / 1) CH₂Cl₂, -15 deg C, 15 min, 2) CH₂Cl₂, from -15 deg C to room temp., 18h

3: 82 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; trifluoroacetic acid; isobutyl chloroformate; 10% palladium on active carbon; In methanol; dichloromethane;
DOI:10.1002/jlac.198219820909

Reference yield:

: 83537-95-5
H-Aib-Aib-O(t-Bu)

: 83537-97-7
Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1) N-methylmorpholine, isobutyl chloroformate / 1) CH₂Cl₂, -15 deg C, 15 min, 2) CH₂Cl₂, from -15 deg C to room temp., 18h

2: 82 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

With 4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane;
DOI:10.1002/jlac.198219820909