(2R,3S)-3--2-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanal

Base Information

Chemical Name:(2R,3S)-3--2-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanal
CAS No.:145655-02-3
Molecular Formula:C₂₈H₄₁NO₄Si
Molecular Weight:483.723
Hs Code.:

(2R,3S)-3-<N-(tert-Butoxycarbonyl)benzylamino>-2-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanal

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-3--2-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanal

Chemical Property:

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Technology Process of (2R,3S)-3--2-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanal

There total 11 articles about (2R,3S)-3--2-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 145655-10-3
(1'R,2'S)-2-<2'-<(N-tert-Butoxycarbonyl)benzylamino>-1'-<(tert-butyldimethylsilyl)oxy>-3'-phenylpropyl>-1,3-thiazole

: 145655-02-3
(2R,3S)-3--2-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanal

Guidance literature:: DOI:10.1016/S0040-4039(00)60888-2

Reference yield:

: 145655-01-2
(1'R,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

: 145655-02-3
(2R,3S)-3--2-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanal

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N, DMAP / dimethylformamide / 1 h / Ambient temperature

2: molecular sieves 4 Angstroem / acetonitrile / 0.25 h / Ambient temperature

3: 1.) NaBH₄, 2.) aq. HgCl₂ / 1.) MeOH, r.t., 10 min, 2.) CH₃CN, r.t., 15 min

With dmap; sodium tetrahydroborate; 4 A molecular sieve; triethylamine; mercury dichloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00129a037

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 145655-02-3
(2R,3S)-3--2-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanal

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N, DMAP / dimethylformamide / 1 h / Ambient temperature

2: molecular sieves 4 Angstroem / acetonitrile / 0.25 h / Ambient temperature

3: 1.) NaBH₄, 2.) aq. HgCl₂ / 1.) MeOH, r.t., 10 min, 2.) CH₃CN, r.t., 15 min

With dmap; sodium tetrahydroborate; 4 A molecular sieve; triethylamine; mercury dichloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00129a037