145655-10-3

Upstream product

• 145655-00-1 2-(N-benzyl-N-tert-butoxycarbonylphenylalanyl)-1,3-thiazole 
• 145654-99-5 (S)-2-(benzyl-tert-butoxycarbonyl-amino)-3-phenyl-propionic acid methyl ester 
• 100-52-7 benzaldehyde 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 68870-85-9 (S)-2-(benzylidene-amino)-3-phenyl-propionic acid methyl ester 
• 66399-75-5 (S)-2-benzylamino-3-phenyl-propionic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 172329-59-8 (3R,5S,1'S)-5-<1'--3'-methylbutyl>-3-(2-methylprop-2-enyl)dihydrofuran-2(3H)-one 
• 172329-58-7 (5S,1'S)-5-<1'--3'-methylbutyl>dihydrofuran-2(3H)-one 
• 172329-61-2 (3R,5S,1'S)-5-<1'--3'-methylbutyl>-3-(2-methylprop-2-enyl)dihydrofuran-2(3H)-one 
• 145655-07-8 (5S,1'S)-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one 
• 145655-11-4 Methyl (4S,5S)-5--4-<(tert-butyldimethylsilyl)oxy>-6-phenyl-2(E)-hexenoate 
• 145655-06-7 Methyl (4S,5S)-5--4-<(tert-butyldimethylsilyl)oxy>-6-phenylhexanoate 
• 145655-08-9 (3R,5S,1'S)-3-Benzyl-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one 
• 145655-09-0 (3R,5S,1'S)-3-Benzyl-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one 
• 98818-41-8 (3R,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one 
• 145655-02-3 (2R,3S)-3--2-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanal 

Relevant academic research and scientific papers

Homologation of L-phenylalanine to ketomethylene and hydroxyethylene dipeptide isosteres via 2-thiazolyl amino ketone intermediate

A highly efficient route is presented for the synthesis of N-protected isosteric dipeptides Pheψ[COCH2]Gly and Pheψ[CH(OH)CH2]Phe from L-phenylalanine through 2-thiazolyl α-amino ketone and δ-amino-γ-hydroxy-(E)-α,β-enoate derivative