(R)-1-phenylethyl 3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-7-<6-fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-oxo-6-heptenoate

Base Information

Chemical Name:(R)-1-phenylethyl 3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-7-<6-fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-oxo-6-heptenoate
CAS No.:130954-96-0
Molecular Formula:C₃₉H₄₅F₂NO₄Si
Molecular Weight:657.873
Hs Code.:

(R)-1-phenylethyl 3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-7-<6-fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-oxo-6-heptenoate

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Chemical Property of (R)-1-phenylethyl 3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-7-<6-fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-oxo-6-heptenoate

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Technology Process of (R)-1-phenylethyl 3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-7-<6-fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-oxo-6-heptenoate

There total 3 articles about (R)-1-phenylethyl 3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-7-<6-fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-oxo-6-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 130955-11-2
6-Fluoro-4-(4-fluoro-phenyl)-2-isopropyl-quinoline-3-carbaldehyde

: 96555-54-3,96555-57-6,130954-95-9
3-(tert-Butyl-dimethyl-silanyloxy)-6-(dimethoxy-phosphoryl)-5-oxo-hexanoic acid (S)-1-phenyl-ethyl ester

: 130954-96-0,130984-01-9
(R)-1-phenylethyl 3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-7-<6-fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-oxo-6-heptenoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In dichloromethane; at -10 ℃; for 1.5h;
DOI:10.1021/jm00105a057

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 130954-96-0,130984-01-9
(R)-1-phenylethyl 3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-7-<6-fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-oxo-6-heptenoate

Guidance literature:: Multi-step reaction with 4 steps

1: p-TSA / toluene / 5 h / Heating

2: DIBAL-H / CH₂Cl₂ / 3 h / -78 °C

3: oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

4: 33 percent / LiCl, DBU / CH₂Cl₂ / 1.5 h / -10 °C

With oxalyl dichloride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In dichloromethane; toluene;
DOI:10.1021/jm00105a057

Reference yield:

: 5220-36-0
2-amino-4',5-difluorobenzophenone

: 130954-96-0,130984-01-9
(R)-1-phenylethyl 3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-7-<6-fluoro-4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-oxo-6-heptenoate

Guidance literature:: Multi-step reaction with 4 steps

1: p-TSA / toluene / 5 h / Heating

2: DIBAL-H / CH₂Cl₂ / 3 h / -78 °C

3: oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 1 h / -78 °C

4: 33 percent / LiCl, DBU / CH₂Cl₂ / 1.5 h / -10 °C

With oxalyl dichloride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In dichloromethane; toluene;
DOI:10.1021/jm00105a057